PXD042649
PXD042649 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | GNPS Understanding the metabolic regulation of murine hematopoietic emergence |
| Description | In vertebrates, lifelong supply of all the blood cell types in suitable numbers is maintained by the hematopoietic stem cells (HSCs). During development, these HSCs emerge in the aorta-gonad-mesonephros (AGM) from specialized vascular endothelium through a transdifferentiation process, called as endothelial-to-hematopoietic transition (EHT). During this process, select endothelial cells (CD31+c-kit- or CD31PCKITN) switch to a hematopoietic transcriptional program, undergo morphological changes and become hemogenic (CD31+c-kit+ or CD31PCKITP) and gives rise to hematopoietic cells (CD31-c-kit+ or CD31NCKITP). A complex interplay of key transcription factors and signaling pathways coordinates the whole process. Specific metabolic signature of a cell can precisely define its phenotype. Evidence has emerged that cellular phenotype and function can be driven according to the changes in cellular metabolism. Metabolic programs, which are stage specific, allow stem cells to adapt their function in different microenvironments. In the present study, we performed nano LC-MS/MS based proteomic analysis to understand the molecular program involved in the transdifferentiation of endothelial to hematopoietic cells. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-02-23 |
| AnnouncementXML | Submission_2024-02-23_08:57:40.359.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Shubham Haribhau Mehatre |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-06-02 03:28:29 | ID requested | |
| ⏵ 1 | 2024-02-23 08:57:41 | announced |
Publication List
| Pv A, Mehatre SH, Verfaillie CM, Alam MT, Khurana S, Glycolytic state of aortic endothelium favors hematopoietic transition during the emergence of definitive hematopoiesis. Sci Adv, 10(7):eadh8478(2024) [pubmed] |
Keyword List
| submitter keyword: Hematopoiesis, AGM, hematopoietic stem cell, hemogenic endothelium, aortic endothelium |
Contact List
| Dr. Satish Khurana | |
|---|---|
| contact affiliation | Indian Institute of Science Education and Research Thiruvananthapuram |
| contact email | satishkhurana@iisertvm.ac.in |
| lab head | |
| Shubham Haribhau Mehatre | |
| contact affiliation | Indian Institute of Science Education and Research-Thiruvananthapuram |
| contact email | shmehatre77@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000092085/ |
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