PXD042631

PXD042631 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling of PPIX-binding proteins between cell types
Description	To use a probe connecting PPIX with biotin to affinity purify interacting proteins in various cell lines. Then to use TMT labeling of the purified proteins, as well as those from controls, to construct data sets of proteins identified with mass spec, together with biostatistical analysis, to distinguish valid interactions for further study. These data may cumulatively allow us to delineate trafficking, signaling, or metabolic pathways related to PPIX binding.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:03:44.178.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zuo-Fei Yuan
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-01 15:26:25	ID requested
1	2023-07-20 12:07:27	announced
⏵ 2	2023-11-14 09:03:48	announced	2023-11-14: Updated project metadata.

Lynch J, Wang Y, Li Y, Kavdia K, Fukuda Y, Ranjit S, Robinson CG, Grace CR, Xia Y, Peng J, Schuetz JD, A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin. Commun Biol, 6(1):673(2023) [pubmed]

submitter keyword: ferroptosis, TMT, PRDX3, reactive oxygen species.,Protoporphyrin IX

John Schuetz
contact affiliation	Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
contact email	John.Schuetz@stjude.org
lab head
Zuo-Fei Yuan
contact affiliation	St. Jude Children's Research Hospital
contact email	zuo-fei.yuan@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042631

PRIDE project URI

• PRIDE
  1. PXD042631
     1. Label: PRIDE project
     2. Name: Proteomic Profiling of PPIX-binding proteins between cell types