PXD042619
PXD042619 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A network medicine approach to elucidate mechanisms underlying menopause-induced knee osteoarthritis |
| Description | This study was aimed at understanding the effects of menopause on knee osteoarthritis, specifically the cartilage proteome. Middle-aged female mice were randomized to receive intraperitoneal injections of either 4-vinylcyclohexene diepoxide (VCD) or sesame oil for 10 consecutive days. Through a serious of validation experiments, we and others have shown that VCD induces a menopausal phenotype, as evidenced by loss of estrus cyclicity and modification to sex hormone profiles. We also showed in our work that VCD injected mice present with more severe cartilage degeneration than sesame oil injected mice. Knee cartilage from the tibial plateau and femoral condyles were microdissected at mid-perimenopause (75 days after the first injection), start of menopause (115 days after the first injection), and late menopause (195 days after the first injection). These times points were chosen since cartilage pathology first presented in the VCD group, but not the sesame oil group, at the start of menopause. Cartilage samples were lyophilized and mass spectrometry proteomics were performed. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-11-05 |
| AnnouncementXML | Submission_2024-11-05_07:09:19.259.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jim Malone |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Deamidated; Glu->pyro-Glu; thioacylation of primary amines - site N-term; Oxidation; Pyro-carbamidomethyl |
| Instrument | Q Exactive Plus; timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-06-01 08:56:48 | ID requested | |
| ⏵ 1 | 2024-11-05 07:09:19 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: menopause, knee osteoarthritis, cartilage, female, mouse, time course |
Contact List
| Fabrisia Ambrosio | |
|---|---|
| contact affiliation | Spaulding Rehabilitation Hospital, Harvard Medical School |
| contact email | fambrosio@mgh.harvard.edu |
| lab head | |
| Jim Malone | |
| contact affiliation | Washington University Sch |
| contact email | jmalone@wustl.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000092077/ |
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