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PXD042607

PXD042607 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePhosphoproteomic dataset comparing wild type, bob1-1 and bob1-1dbf4∆ cells in M-phase arrested S.cerevisiae.
DescriptionDNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, repair pathway choice – the cellular decision making underlying DSB repair – occurs at the level of DSB resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependent kinases (CDKs) phosphorylate resection proteins and thereby stimulate DSB resection and repair by homologous recombination (HR). We uncovered a novel role for the Dbf4-dependent kinase Cdc7 (DDK) in regulating HR and DNA end resection. We therefore analyzed phosphorylation substrates of DDK by phosphoproteomics, where we compared wild type, bob1-1 and bob1-1dbf4∆ cells in M-phase arrested S.cerevisiae.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:30:07.522.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBarbara Steigenberger
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListphosphorylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-01 03:25:53ID requested
12024-02-15 11:18:09announced
22024-10-22 06:30:07announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: DDK, Dbf4-Cdc7, cell-cycle,Saccharomyces cerevisiae
Contact List
Prof. Dr. Boris Pfander
contact affiliationInstitute of Aerospace Medicine German Aerospace Center (DLR) Linder Höhe 51147 Cologne, Germany Phone: +49-2203-6011-277 Email: boris.pfander@dlr.de & Institute for Genome Stability in Ageing and Disease University of Cologne CECAD Research Center Joseph-Stelzmann-Str. 26 50931 Cologne, Germany Email: bpfander@uni-koeln.de & Max-Planck Institute of Biochemistry, Am Klopferspitz 18 82152 Martinsried, Germany Phone:+49-89-8578-3050 Fax: +49-89-8578-2454, Email: bpfander@biochem.mpg.de
contact emailbpfander@biochem.mpg.de
lab head
Barbara Steigenberger
contact affiliationMPI of Biochemistry
contact emailsteigenberger@biochem.mpg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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