PXD042607 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomic dataset comparing wild type, bob1-1 and bob1-1dbf4∆ cells in M-phase arrested S.cerevisiae. |
Description | DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, repair pathway choice – the cellular decision making underlying DSB repair – occurs at the level of DSB resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependent kinases (CDKs) phosphorylate resection proteins and thereby stimulate DSB resection and repair by homologous recombination (HR). We uncovered a novel role for the Dbf4-dependent kinase Cdc7 (DDK) in regulating HR and DNA end resection. We therefore analyzed phosphorylation substrates of DDK by phosphoproteomics, where we compared wild type, bob1-1 and bob1-1dbf4∆ cells in M-phase arrested S.cerevisiae. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:30:07.522.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Barbara Steigenberger |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-01 03:25:53 | ID requested | |
1 | 2024-02-15 11:18:09 | announced | |
⏵ 2 | 2024-10-22 06:30:07 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: DDK, Dbf4-Cdc7, cell-cycle,Saccharomyces cerevisiae |
Contact List
Prof. Dr. Boris Pfander |
contact affiliation | Institute of Aerospace Medicine German Aerospace Center (DLR) Linder Höhe 51147 Cologne, Germany Phone: +49-2203-6011-277 Email: boris.pfander@dlr.de & Institute for Genome Stability in Ageing and Disease University of Cologne CECAD Research Center Joseph-Stelzmann-Str. 26 50931 Cologne, Germany Email: bpfander@uni-koeln.de & Max-Planck Institute of Biochemistry, Am Klopferspitz 18 82152 Martinsried, Germany Phone:+49-89-8578-3050 Fax: +49-89-8578-2454, Email: bpfander@biochem.mpg.de |
contact email | bpfander@biochem.mpg.de |
lab head | |
Barbara Steigenberger |
contact affiliation | MPI of Biochemistry |
contact email | steigenberger@biochem.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042607
- Label: PRIDE project
- Name: Phosphoproteomic dataset comparing wild type, bob1-1 and bob1-1dbf4∆ cells in M-phase arrested S.cerevisiae.