PXD042602
PXD042602 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dietary dodecanedioc acid increases metabolic rate and protects against obesity |
| Description | Reduced metabolic capacity is a hallmark of numerous rare genetic diseases as well as more common disease states such as obesity, diabetes, heart disease, and neurological disorders. However, therapies that stimulate energy metabolism are lacking. Here, we show that substituting ~2/3 of the lipid in a high-fat rodent diet with dodecanedioc acid, a 12-carbon dicarboxylic fatty acid (DC12), increases metabolic rate, reduces body fat, reduces liver fat, and improves glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escapes first-pass liver metabolism and is metabolized by many tissues. In tissues expressing the a isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened as far as the TCA cycle intermediate succinyl-CoA, which may partially explain the increased metabolic rate. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. DC12 was catabolized even by adipose tissue and cannot be stored intracellularly like other fat sources. Finally, we demonstrate that dicarboxylic acids are a useful alternative energy source to improve metabolic function in a mouse model of long-chain fatty acid oxidation disorders. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-05-17 |
| AnnouncementXML | Submission_2024-05-17_09:01:26.846.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Joanna Bons |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | N6-succinyl-L-lysine |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-05-31 22:27:07 | ID requested | |
| ⏵ 1 | 2024-05-17 09:01:27 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Dodecanedioc acid, Succinate pro-drug, Succinylation, Quantitative proteomics, Data-independent acquisition (DIA), Acyl-CoA oxidase-1 (ACOX1), Parallel reaction monitoring (PRM) |
Contact List
| Birgit Schilling | |
|---|---|
| contact affiliation | Buck Institute |
| contact email | bschilling@buckinstitute.org |
| lab head | |
| Joanna Bons | |
| contact affiliation | Buck Institute for Research on Aging |
| contact email | jbons@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v05/MSV000092073/ |
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