PXD042594

PXD042594 is an original dataset announced via ProteomeXchange.

Title	ROS are evolutionary conserved cell-to-cell stress signals
Description	Cell-to-cell communication is fundamental to multicellular organisms and unicellular organisms living in a microbiome. It is thought to have evolved as a stress- or quorum-sensing mechanism in unicellular organisms. A unique cell-to-cell communication mechanism that uses reactive oxygen species (ROS) as a signal (termed the ‘ROS wave’) was identified in flowering plants. This process is essential for systemic signaling and plant acclimation to stress and can spread from a small group of cells to the entire plant within minutes. Whether a similar signaling process is found in other organisms is however unknown. Here we report that the ROS wave can be found in unicellular algae, amoeba, ferns, mosses, mammalian cells, and isolated hearts. We further show that this process can be triggered in unicellular and multicellular organisms by a local stress or H2O2 treatment and blocked by the application of catalase or NADPH oxidase inhibitors, and that in unicellular algae it communicates important stress-response signals between cells. Taken together, our findings suggest that an active process of cell-to-cell ROS signaling, like the ROS wave, evolved before unicellular and multicellular organisms diverged. This mechanism could have communicated an environmental stress signal between cells and coordinated the acclimation response of many different cells living in a community. The finding of a signaling process, like the ROS wave, in mammalian cells further contributes to our understanding of different diseases and could impact the development of new drugs that target for example cancer or heart disease.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:47.984.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thao Thi Nguyen
SpeciesList	scientific name: Chlamydomonas reinhardtii; NCBI TaxID: 3055;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-31 15:16:57	ID requested
1	2024-05-24 03:12:01	announced
⏵ 2	2024-10-22 06:42:50	announced	2024-10-22: Updated project metadata.

10.1073/pnas.2305496120;

Fichman Y, Rowland L, Oliver MJ, Mittler R, ROS are evolutionary conserved cell-to-cell stress signals. Proc Natl Acad Sci U S A, 120(31):e2305496120(2023) [pubmed]

submitter keyword: DIA-PASEF,Reactive oxygen species (ROS), Cell-to-cell communication

Ron Mittler
contact affiliation	University of Missouri
contact email	mittlerr@missouri.edu
lab head
Thao Thi Nguyen
contact affiliation	University of Missouri-Columbia
contact email	tnguyen24@wisc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD042594

PRIDE project URI

• PRIDE
  1. PXD042594
     1. Label: PRIDE project
     2. Name: ROS are evolutionary conserved cell-to-cell stress signals