PXD042583

PXD042583 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phosphoproteomics evaluation of the effect of GLP-1 on the porcine pacemaker
Description	GLP-1 induces an increase in heart rate, but its mechanism remains elusive. We used a phosphoproteomic approach to evaluate the effect of GLP-1 on the porcine sinus node. Tissue samples from the sinus node region and left ventricle were collected from eight animals following a 60-minute infusion with either GLP-1 or saline. We employed a tandem mass tag (TMT) labeling strategy to multiplex samples, enriched for phosphorylated peptides by titanium dioxide chromatography, and pre-fractionated the resulting peptide pool prior to LC-MS/MS measurements on an Orbitrap Ascend Tribrid mass spectrometer.
HostingRepository	PRIDE
AnnounceDate	2024-06-10
AnnouncementXML	Submission_2024-06-10_02:26:12.019.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jonathan Achter
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-31 09:24:06	ID requested
⏵ 1	2024-06-10 02:26:12	announced

Publication List

10.1093/cvr/cvae120;
Lubberding AF, Veedfald S, Achter JS, Nissen SD, Soattin L, Sorrentino A, Vega ET, Linz B, Eggertsen CHE, Mulvey J, Tor, ä, ng S, Larsen SA, Nissen A, Petersen LG, Bilir SE, Bentzen BH, Rosenkilde MM, Hartmann B, Lille, ø, r TNB, Qazi S, M, ø, ller CH, Tfelt-Hansen J, Sattler SM, Jespersen T, Holst JJ, Lundby A, Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node. Cardiovasc Res, 120(12):1427-1441(2024) [pubmed]

10.1093/cvr/cvae120;

Lubberding AF, Veedfald S, Achter JS, Nissen SD, Soattin L, Sorrentino A, Vega ET, Linz B, Eggertsen CHE, Mulvey J, Tor, ä, ng S, Larsen SA, Nissen A, Petersen LG, Bilir SE, Bentzen BH, Rosenkilde MM, Hartmann B, Lille, ø, r TNB, Qazi S, M, ø, ller CH, Tfelt-Hansen J, Sattler SM, Jespersen T, Holst JJ, Lundby A, Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node. Cardiovasc Res, 120(12):1427-1441(2024) [pubmed]

Keyword List

submitter keyword: Heart, Phosphoproteomics, Pig, Pacemaker, glucagon-like peptide 1, Porcine, GLP-1, Sinus node

submitter keyword: Heart, Phosphoproteomics, Pig, Pacemaker, glucagon-like peptide 1, Porcine, GLP-1, Sinus node

Contact List

Alicia Lundby
contact affiliation	Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
contact email	alicia.lundby@sund.ku.dk
lab head
Jonathan Achter
contact affiliation	University of Copenhagen
contact email	jonathan.achter@sund.ku.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD042583
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD042583

PRIDE project URI

Repository Record List

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