PXD042528
PXD042528 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | High-Throughput Intact Glycopeptide Quantification Strategy with Targeted-MS (HTiGQs-Target) Reveals Site-Specific IgG N-Glycopeptides as Biomarkers for Hepatic Disorder Diagnosis and Staging |
| Description | We developed a high-throughput targeted quantification strategy for intact glycopeptides (HTiGQs-Target) to diagnose and differentiate the malignancy of liver diseases. The method involves two-step labeling. This step derivatization makes the same parent ions in different samples produce sufficient mass differences in primary mass spectrometry detection, and finally expands the sample detection throughput to 20 (2*10) samples per run. We used this method to analyze serum samples from patients with different types and stages of liver diseases, and found some glycopeptide features with diagnostic and differential significance. This project provides a new and efficient proteomics method for early diagnosis and treatment of liver diseases. |
| HostingRepository | iProX |
| AnnounceDate | 2023-05-30 |
| AnnouncementXML | Submission_2024-05-29_21:48:03.433.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xuejiao Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-05-29 22:05:23 | ID requested | |
| ⏵ 1 | 2024-05-29 21:48:04 | announced |
Publication List
| Liu X, Fu B, Chen J, Sun Z, Zheng D, Li Z, Gu B, Zhang Y, Lu H, High-throughput intact Glycopeptide quantification strategy with targeted-MS (HTiGQs-target) reveals site-specific IgG N-glycopeptides as biomarkers for hepatic disorder diagnosis and staging. Carbohydr Polym, 325():121499(2024) [pubmed] |
Keyword List
| submitter keyword: liver disease, biomarker, IgG N-Glycopeptides, parallel reaction monitoring, High-throughput, targeted mass spectrometry |
Contact List
| Haojie Lu | |
|---|---|
| contact affiliation | Fudan University |
| contact email | luhaojie@fudan.edu.cn |
| lab head | |
| Xuejiao Liu | |
| contact affiliation | Fudan University |
| contact email | 1060910692@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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