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PXD042528

PXD042528 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHigh-Throughput Intact Glycopeptide Quantification Strategy with Targeted-MS (HTiGQs-Target) Reveals Site-Specific IgG N-Glycopeptides as Biomarkers for Hepatic Disorder Diagnosis and Staging
DescriptionWe developed a high-throughput targeted quantification strategy for intact glycopeptides (HTiGQs-Target) to diagnose and differentiate the malignancy of liver diseases. The method involves two-step labeling. This step derivatization makes the same parent ions in different samples produce sufficient mass differences in primary mass spectrometry detection, and finally expands the sample detection throughput to 20 (2*10) samples per run. We used this method to analyze serum samples from patients with different types and stages of liver diseases, and found some glycopeptide features with diagnostic and differential significance. This project provides a new and efficient proteomics method for early diagnosis and treatment of liver diseases.
HostingRepositoryiProX
AnnounceDate2023-05-30
AnnouncementXMLSubmission_2024-05-29_21:48:03.433.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXuejiao Liu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-29 22:05:23ID requested
12024-05-29 21:48:04announced
Publication List
Liu X, Fu B, Chen J, Sun Z, Zheng D, Li Z, Gu B, Zhang Y, Lu H, High-throughput intact Glycopeptide quantification strategy with targeted-MS (HTiGQs-target) reveals site-specific IgG N-glycopeptides as biomarkers for hepatic disorder diagnosis and staging. Carbohydr Polym, 325():121499(2024) [pubmed]
Keyword List
submitter keyword: liver disease, biomarker, IgG N-Glycopeptides, parallel reaction monitoring, High-throughput, targeted mass spectrometry
Contact List
Haojie Lu
contact affiliationFudan University
contact emailluhaojie@fudan.edu.cn
lab head
Xuejiao Liu
contact affiliationFudan University
contact email1060910692@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI