PXD042517

PXD042517 is an original dataset announced via ProteomeXchange.

Title	Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit
Description	Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. The role of transient cell types and circuits have been vastly addressed in neocortical regions, but poorly studied in the hippocampus. To understand how CR cells persistence influences the maturation of hippocampal circuits, we specifically ablated CR cells from the postnatal hippocampus. We observed layer-specific changes in the dendritic complexity and spine density of CA1 pyramidal cells. We were able to identify significant changes in the expression levels of Latrophilin-2, a postsynaptic guidance molecule known for its role in the entorhinal-hippocampal connectivity. Those findings were supported by changes in the overall synaptic proteomic content in CA1 Stratum Lacunosum-Moleculare.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:53.959.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maike Krause
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-27 12:09:07	ID requested
1	2024-05-24 03:42:46	announced
⏵ 2	2024-10-22 06:42:54	announced	2024-10-22: Updated project metadata.

Gl, æ, rum IL, Dunville K, Moan K, Krause M, Montaldo NP, Kirikae H, Nigro MJ, S, æ, trom P, van Loon B, Quattrocolo G, Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit. Development, 151(1):(2024) [pubmed]

10.1242/dev.202236;

submitter keyword: Cajal-Retzius cells, hippocampus, CA1 SLM, viral vector injection, development, cell ablation, brain tissue, transgenic mouse line, hippocampal circuit, LC-MS/MS

Giulia Quattrocolo
contact affiliation	Group Leader, Quattrocolo Lab, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway
contact email	giulia.quattrocolo@ntnu.no
lab head
Maike Krause
contact affiliation	Kavli Institute for Systems Neuroscience and Center for Neural Computation Norwegian University of Science and Technology (NTNU) Trondheim 7491
contact email	maike.krause@ntnu.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD042517

PRIDE project URI

• PRIDE
  1. PXD042517
     1. Label: PRIDE project
     2. Name: Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit