PXD042517 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit |
Description | Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. The role of transient cell types and circuits have been vastly addressed in neocortical regions, but poorly studied in the hippocampus. To understand how CR cells persistence influences the maturation of hippocampal circuits, we specifically ablated CR cells from the postnatal hippocampus. We observed layer-specific changes in the dendritic complexity and spine density of CA1 pyramidal cells. We were able to identify significant changes in the expression levels of Latrophilin-2, a postsynaptic guidance molecule known for its role in the entorhinal-hippocampal connectivity. Those findings were supported by changes in the overall synaptic proteomic content in CA1 Stratum Lacunosum-Moleculare. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:42:53.959.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maike Krause |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-05-27 12:09:07 | ID requested | |
1 | 2024-05-24 03:42:46 | announced | |
⏵ 2 | 2024-10-22 06:42:54 | announced | 2024-10-22: Updated project metadata. |
Publication List
Gl, æ, rum IL, Dunville K, Moan K, Krause M, Montaldo NP, Kirikae H, Nigro MJ, S, æ, trom P, van Loon B, Quattrocolo G, Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit. Development, 151(1):(2024) [pubmed] |
10.1242/dev.202236; |
Keyword List
submitter keyword: Cajal-Retzius cells, hippocampus, CA1 SLM, viral vector injection, development, cell ablation, brain tissue, transgenic mouse line, hippocampal circuit, LC-MS/MS |
Contact List
Giulia Quattrocolo |
contact affiliation | Group Leader, Quattrocolo Lab, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway |
contact email | giulia.quattrocolo@ntnu.no |
lab head | |
Maike Krause |
contact affiliation | Kavli Institute for Systems Neuroscience and Center for Neural Computation Norwegian University of Science and Technology (NTNU) Trondheim 7491 |
contact email | maike.krause@ntnu.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042517
- Label: PRIDE project
- Name: Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit