PXD042507

PXD042507 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis of liver proteins from WT and db/db mice
Description	Liver is a key organ which controls glucose and lipid homeostasis. Dysregulation of hepatic glucose and lipid metabolism causes metabolic diseases, including type 2 diabetes (T2D) and metabolic-associated liver diseases (MAFLD). However, how glucose and lipid homeostasis are integratively regulated is not fully understood. The key factors that drive the pathogenesis of metabolic diseases need to be identified. To identify these regulators, we performed quantitative proteomic analysis in the livers of wide type and db/db mice (n=4 for each group). The quantitative proteomic analysis showed that 1233 proteins were upregulated and 2724 proteins were downregulated in the livers of db/db mice. These differentially regulated proteins contribute to the pathogenesis of metabolic diseases.
HostingRepository	PRIDE
AnnounceDate	2025-02-28
AnnouncementXML	Submission_2025-02-27_18:29:44.535.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kaixin Ding
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-25 20:19:43	ID requested
⏵ 1	2025-02-27 18:29:44	announced

10.1126/SCIENCE.ADP4120;

submitter keyword: Mouse,Liver,LC-MSMS

Zheng Chen
contact affiliation	HIT Center for Life Sciences,Harbin Institute of Technology,China
contact email	chenzheng@hit.edu.cn
lab head
kaixin Ding
contact affiliation	15244605452
contact email	908312641@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042507
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis of liver proteins from WT and db/db mice