PXD042499

PXD042499 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Ezrin inhibition overcomes acquired resistance to vemurafenib in BRAFV600E-mutated colon cancer and melanoma cells in vitro
Description	In spite of the advancements in targeted therapy for BRAFV600E-mutated metastatic colorectal cancer (mCRC), the development of resistance to BRAFV600E inhibition limits the response rate and durability of the treatment. Better understanding of the resistance mechanisms to BRAF inhibitors will facilitate the design of novel pharmacological strategies for BRAF-mutated mCRC. The aim of this study was to identify novel protein candidates involved in acquired resistance to BRAFV600E inhibitor vemurafenib in BRAFV600E-mutated colon cancer cells using an integrated proteomics approach. Our study suggests a role of ezrin in acquired resistance to vemurafenib in colon cancer and melanoma cells carrying BRAFV600E mutation and supports further pre-clinical and clinical studies to explore the benefits of combined BRAF inhibitors and actin-targeting drugs as a potential therapeutic approach for BRAFV600E-mutated cancers.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:55.141.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antje Dittmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-25 08:46:22	ID requested
1	2023-08-29 02:38:24	announced
⏵ 2	2023-11-14 09:05:02	announced	2023-11-14: Updated project metadata.

Publication List

Car I, Dittmann A, Vasieva O, Bo, č, kor L, Grb, č, i, ć P, Pite, š, a N, Klobu, č, ar M, Kraljevi, ć, Paveli, ć S, Sedi, ć M, Ezrin Inhibition Overcomes Acquired Resistance to Vemurafenib in BRAFV600E-Mutated Colon Cancer and Melanoma Cells In Vitro. Int J Mol Sci, 24(16):(2023) [pubmed]

Car I, Dittmann A, Vasieva O, Bo, č, kor L, Grb, č, i, ć P, Pite, š, a N, Klobu, č, ar M, Kraljevi, ć, Paveli, ć S, Sedi, ć M, Ezrin Inhibition Overcomes Acquired Resistance to Vemurafenib in BRAFV600E-Mutated Colon Cancer and Melanoma Cells In Vitro. Int J Mol Sci, 24(16):(2023) [pubmed]

Keyword List

ProteomeXchange project tag: EPIC-XS
submitter keyword: ezrin,BRAFV600E, actin cytoskeleton, NSC305787, colon cancer, ezrin inhibitor, melanoma, BRAF inhibitor, vemurafenib

ProteomeXchange project tag: EPIC-XS

submitter keyword: ezrin,BRAFV600E, actin cytoskeleton, NSC305787, colon cancer, ezrin inhibitor, melanoma, BRAF inhibitor, vemurafenib

Contact List

Mirela Sedic
contact affiliation	Centre for Applied Bioanthropology, Institute for Anthropological Research, Zagreb, Croatia
contact email	mirela.sedic@inantro.hr
lab head
Antje Dittmann
contact affiliation	ETH
contact email	antje.dittmann@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD042499
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD042499

PRIDE project URI

Repository Record List

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