PXD042393

PXD042393 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis identifies proteins related to insulin resistance
Description	Illuminating the mechanisms controlling glucose homeostasis may deepen our understanding of the pathogenesis of T2DM and extend our armamentarium of medications for more specific and tailored treatment of T2DM in future. Employing gain-of-function and loss-of-function approaches, we previously established the role of hepatic Dyrk1b in systemic glucose homeostasis and insulin resitance. To analyze the mechnisms for Dyrk1b in regulation of glucose homeostasis and insulin signaling, TMT-based quantitative proteomics were performed in livers of Dyrk1b overexpression mice and control mice. In this study, we identified 599 differentially expressed proteins (DEPs) in Dyrk1b overexpression mice and verified some of them by western blot. Our findings will advance the understanding of the mechanisms of glycemic control and the pathogenesis of T2DM.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:37:48.521.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lianju Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-22 05:32:29	ID requested
⏵ 1	2025-05-06 09:37:49	announced

Publication List

Li L, Zou Y, Shen C, Chen N, Tong M, Liu R, Wang J, Ning G, Hepatic Dyrk1b impairs systemic glucose homeostasis by modulating Wbp2 expression in a kinase activity-dependent manner. Heliyon, 10(17):e36726(2024) [pubmed]
10.1016/j.heliyon.2024.e36726;

Li L, Zou Y, Shen C, Chen N, Tong M, Liu R, Wang J, Ning G, Hepatic Dyrk1b impairs systemic glucose homeostasis by modulating Wbp2 expression in a kinase activity-dependent manner. Heliyon, 10(17):e36726(2024) [pubmed]

10.1016/j.heliyon.2024.e36726;

Keyword List

submitter keyword: T2DM
Insulin resistance
TMT;

submitter keyword: T2DM

Insulin resistance

TMT;

Contact List

Jiqiu Wang
contact affiliation	Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
contact email	wangjq@shsmu.edu.cn
lab head
Lianju Li
contact affiliation	Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
contact email	lilianju5678@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD042393
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD042393

PRIDE project URI

Repository Record List

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