PXD042374

PXD042374 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	MOE silencing of DUX4 in FSHD and UASB myoblasts
Description	Proteomic studies in facioscapulohumeral muscular dystrophy (FSHD) could offer new insight to disease mechanisms underpinned by post-transcriptional processes. We used stable isotope (deuterium oxide; D2O) labelling and peptide mass spectrometry to investigate the abundance and turnover rates of proteins in cultured muscle cells from 2 individuals affected by FSHD and their unaffected siblings (UASb). Cells were treated with or without MOE to silence DUX4
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:01:36.463.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD042374
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jatin Burniston
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-21 11:14:08	ID requested
1	2023-06-27 03:59:15	announced
⏵ 2	2023-11-14 09:01:37	announced	2023-11-14: Updated project metadata.

Publication List

Nishimura Y, Bittel AJ, Stead CA, Chen YW, Burniston JG, Facioscapulohumeral Muscular Dystrophy is Associated With Altered Myoblast Proteome Dynamics. Mol Cell Proteomics, 22(8):100605(2023) [pubmed]
10.6019/PXD042374;

Nishimura Y, Bittel AJ, Stead CA, Chen YW, Burniston JG, Facioscapulohumeral Muscular Dystrophy is Associated With Altered Myoblast Proteome Dynamics. Mol Cell Proteomics, 22(8):100605(2023) [pubmed]

10.6019/PXD042374;

Keyword List

submitter keyword: Human, Q-Exactive

submitter keyword: Human, Q-Exactive

Contact List

Jatin G Burniston
contact affiliation	Liverpool John Moores University
contact email	j.burniston@ljmu.ac.uk
lab head
Jatin Burniston
contact affiliation	Liverpool John Moores University
contact email	j.burniston@ljmu.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD042374
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD042374

PRIDE project URI

Repository Record List

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