PXD042328

PXD042328 is an original dataset announced via ProteomeXchange.

Title	Kinome profiling of patient JMML samples pre- and post-trametinib treatment
Description	Juvenile myelomonocytic leukemia (JMML) is an aggressive cancer of young children initiated by mutations in NRAS, KRAS and other genes encoding proteins that modulate Ras signal output. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment and patients with relapsed and refractory disease have dismal outcomes. This trial evaluated the safety and efficacy of trametinib in advanced JMML. Kinase enrichment proteomic analysis was performed using available patient samples pre- or post-treatment with trametinib (NCT03190915) to evaluate the effects on the functional kinome.
HostingRepository	PRIDE
AnnounceDate	2024-04-23
AnnouncementXML	Submission_2024-04-23_06:24:18.338.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steven Angus
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-18 08:59:05	ID requested
⏵ 1	2024-04-23 06:24:18	announced

Dataset with its publication pending

submitter keyword: Juvenile myelomonocytic leukemia, MEK1/2 inhibitor, multiplexed kinase inhibitor bead affinity chromatography, clinical trial

Elliot Stieglitz
contact affiliation	UCSF Benioff Children’s Hospitals
contact email	Elliot.Stieglitz@ucsf.edu
lab head
Steven Angus
contact affiliation	Indiana University School of Medicine
contact email	sangus@iu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD042328

PRIDE project URI

• PRIDE
  1. PXD042328
     1. Label: PRIDE project
     2. Name: Kinome profiling of patient JMML samples pre- and post-trametinib treatment