PXD042319

PXD042319 is an original dataset announced via ProteomeXchange.

Title	muscular changes upon desmin mutation
Description	a knockin mouse model was generatded that expresses the desmin mutant R405W either heterozygotic or homozygotic. the soleus muscle from 6 wt animals and each 6 aniamls with either heterzygotic or homozygotic mutation of desmin were extracted and embedded for cryotome sectioning. Muscle sections from 10 µm slices were collected in an eppendorf vial for proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2025-11-10
AnnouncementXML	Submission_2025-11-09_16:07:44.333.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Schmidt
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-18 05:28:23	ID requested
⏵ 1	2025-11-09 16:07:45	announced

Batonnet-Pichon S, Delort F, Lilienbaum A, Berwanger C, Schultheis D, Schl, ö, tzer-Schrehardt U, Schmidt A, Uebe S, Baiche Y, Eisenack TJ, Trentini DB, Mallek M, Mill L, Ferreiro A, Eberhard B, L, ü, cke T, Kr, ü, ger M, Thiel C, Schr, ö, der R, Clemen CS, R405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy. J Cachexia Sarcopenia Muscle, 16(6):e70094(2025) [pubmed]

10.1002/jcsm.70094;

submitter keyword: demin, tissue, fiber, muscle

Markus Krüger
contact affiliation	Cecad, Department of Genetics, University of Cologne
contact email	mkrueg13@uni-koeln.de
lab head
Andreas Schmidt
contact affiliation	1. Bruker Daltonics GmbH & Co KG, Bremen
contact email	andreasschmidt.le@web.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD042319

PRIDE project URI

• PRIDE
  1. PXD042319
     1. Label: PRIDE project
     2. Name: muscular changes upon desmin mutation