PXD042316
PXD042316 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Presentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles |
Description | Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in this disease is its highly conserved driver mutation: a gene fusion between DNAJB1 and PRKACA, which is expressed in virtually all FLC tumors and could be an ideal neoantigen target for immunotherapy. In this study, we aimed to define endogenous CD8 T cell responses to this fusion in FLC patients and evaluate fusion-specific T cell receptors (TCRs) as candidates for novel cellular immunotherapies. Although fusion-specific T cells in FLC appear to be rare, we nevertheless defined an endogenous functional T cell response in an FLC patient. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:42:37.143.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD042316 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Kirti Pandey |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue |
Instrument | timsTOF Pro 2 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-05-18 02:36:58 | ID requested | |
1 | 2024-05-24 02:18:10 | announced | |
⏵ 2 | 2024-10-22 06:42:45 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.6019/PXD042316; |
Kirk AM, Crawford JC, Chou CH, Guy C, Pandey K, Kozlik T, Shah RK, Chung S, Nguyen P, Zhang X, Wang J, Bell M, Mettelman RC, Allen EK, Pogorelyy MV, Kim H, Minervina AA, Awad W, Bajracharya R, White T, Long D, Gordon B, Morrison M, Glazer ES, Murphy AJ, Jiang Y, Fitzpatrick EA, Yarchoan M, Sethupathy P, Croft NP, Purcell AW, Federico SM, Stewart E, Gottschalk S, Zamora AE, DeRenzo C, Strome SE, Thomas PG, cell responses that potentiate cell therapy for fibrolamellar carcinoma. Cell Rep Med, 5(3):101469(2024) [pubmed] |
10.1016/j.xcrm.2024.101469; |
Keyword List
submitter keyword: fusion neoantigens, HLA class I, CD8 T cell,DNAJB1-PRKACA, Fibrolamellar carcinoma |
Contact List
Anthony Wayne Purcell | |
---|---|
contact affiliation | Department of Biochemistry, Monash University, Clayton,3168, Australia |
contact email | anthony.purcell@monash.edu |
lab head | |
Kirti Pandey | |
contact affiliation | Monash University |
contact email | kirti.pandey1@monash.edu |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD042316 |
PRIDE project URI |
Repository Record List
[ + ]