PXD042311
PXD042311 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovery of 180055 as a PROTAC degrader for Treating Cancers |
| Description | PARP1 is an abundant nuclear protein that is involved in a number of biological processes linked to cellular stress responses. PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). In this work we discovered a PROTAC degrader of PARP1 -180055, which uncoupled PARP1 trapping and inhibition. Moreover, 180055 has great potential for treating cancers. |
| HostingRepository | iProX |
| AnnounceDate | 2023-05-18 |
| AnnouncementXML | Submission_2024-12-23_20:30:29.912.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Li Chen |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-05-18 00:27:19 | ID requested | |
| 1 | 2023-05-18 00:27:35 | announced | |
| ⏵ 2 | 2024-12-23 20:30:30 | announced | 2024-12-24: Add Publication. |
Publication List
| Chen L, Zou Y, Sun R, Huang M, Zhu X, Tang X, Yang X, Li D, Fan G, Wang Y, Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader. Cell Death Dis, 15(12):898(2024) [pubmed] |
Keyword List
| submitter keyword: PARP1 degradation, PROTAC, DNA trapping, cancer cell |
Contact List
| Gaofeng Fan | |
|---|---|
| contact affiliation | Shanghai Tech University |
| contact email | fangf@shanghaitech.edu.cn |
| lab head | |
| Li Chen | |
| contact affiliation | Shanghai Tech University |
| contact email | chenli0096@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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