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PXD042311

PXD042311 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDiscovery of 180055 as a PROTAC degrader for Treating Cancers
DescriptionPARP1 is an abundant nuclear protein that is involved in a number of biological processes linked to cellular stress responses. PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). In this work we discovered a PROTAC degrader of PARP1 -180055, which uncoupled PARP1 trapping and inhibition. Moreover, 180055 has great potential for treating cancers.
HostingRepositoryiProX
AnnounceDate2023-05-18
AnnouncementXMLSubmission_2024-12-23_20:30:29.912.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLi Chen
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-18 00:27:19ID requested
12023-05-18 00:27:35announced
22024-12-23 20:30:30announced2024-12-24: Add Publication.
Publication List
Chen L, Zou Y, Sun R, Huang M, Zhu X, Tang X, Yang X, Li D, Fan G, Wang Y, Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader. Cell Death Dis, 15(12):898(2024) [pubmed]
Keyword List
submitter keyword: PARP1 degradation, PROTAC, DNA trapping, cancer cell
Contact List
Gaofeng Fan
contact affiliationShanghai Tech University
contact emailfangf@shanghaitech.edu.cn
lab head
Li Chen
contact affiliationShanghai Tech University
contact emailchenli0096@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI