⮝ Full datasets listing

PXD042293

PXD042293 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNovel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire
DescriptionInvertebrate antimicrobial peptides (AMPs) form the first line of defence against pathogenic microbes. Understanding AMP profiles in helminths, their importance to helminth biology, and how they shape microbial communities could reveal novel approaches for anthelmintic and/or antimicrobial development. In this study, we employed a LC-MS/MS peptidomics pipeline to validate a novel integrated homology- and computational-based pipeline for the discovery of helminth AMPs. Our peptidomics pipeline found 60 high-confidence PSMs correlating to 15 high-confidence novel AMP-LPs within Ascaris suum body-cavity fluid supporting the need for further characterisation of these peptides and their functions within helminths.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:58:02.485.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDarrin McKenzie
SpeciesList scientific name: Ascaris suum; NCBI TaxID: 6253;
ModificationListsulfated residue; amidated residue; 2-pyrrolidone-5-carboxylic acid (Glu); 2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-17 09:38:38ID requested
12023-07-26 07:03:53announced
22023-11-14 06:44:25announced2023-11-14: Updated project metadata.
32024-10-22 05:58:02announced2024-10-22: Updated project metadata.
Publication List
10.1371/JOURNAL.PPAT.1011508;
Keyword List
submitter keyword: Peptidomics, Helminths,Antimicrobial Peptides
Contact List
Prof Angela Mousley
contact affiliationMicrobes & Pathogen Biology, The Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom
contact emailA.Mousley@qub.ac.uk
lab head
Darrin McKenzie
contact affiliationQueen's University Belfast
contact emaildmckenzie02@qub.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042293
PRIDE project URI
Repository Record List
[ + ]