PXD042293 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire |
Description | Invertebrate antimicrobial peptides (AMPs) form the first line of defence against pathogenic microbes. Understanding AMP profiles in helminths, their importance to helminth biology, and how they shape microbial communities could reveal novel approaches for anthelmintic and/or antimicrobial development. In this study, we employed a LC-MS/MS peptidomics pipeline to validate a novel integrated homology- and computational-based pipeline for the discovery of helminth AMPs. Our peptidomics pipeline found 60 high-confidence PSMs correlating to 15 high-confidence novel AMP-LPs within Ascaris suum body-cavity fluid supporting the need for further characterisation of these peptides and their functions within helminths. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:58:02.485.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Darrin McKenzie |
SpeciesList | scientific name: Ascaris suum; NCBI TaxID: 6253; |
ModificationList | sulfated residue; amidated residue; 2-pyrrolidone-5-carboxylic acid (Glu); 2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue |
Instrument | TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-05-17 09:38:38 | ID requested | |
1 | 2023-07-26 07:03:53 | announced | |
2 | 2023-11-14 06:44:25 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 05:58:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Peptidomics, Helminths,Antimicrobial Peptides |
Contact List
Prof Angela Mousley |
contact affiliation | Microbes & Pathogen Biology, The Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom |
contact email | A.Mousley@qub.ac.uk |
lab head | |
Darrin McKenzie |
contact affiliation | Queen's University Belfast |
contact email | dmckenzie02@qub.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042293 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042293
- Label: PRIDE project
- Name: Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire