PXD042293

PXD042293 is an original dataset announced via ProteomeXchange.

Title	Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire
Description	Invertebrate antimicrobial peptides (AMPs) form the first line of defence against pathogenic microbes. Understanding AMP profiles in helminths, their importance to helminth biology, and how they shape microbial communities could reveal novel approaches for anthelmintic and/or antimicrobial development. In this study, we employed a LC-MS/MS peptidomics pipeline to validate a novel integrated homology- and computational-based pipeline for the discovery of helminth AMPs. Our peptidomics pipeline found 60 high-confidence PSMs correlating to 15 high-confidence novel AMP-LPs within Ascaris suum body-cavity fluid supporting the need for further characterisation of these peptides and their functions within helminths.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:58:02.485.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Darrin McKenzie
SpeciesList	scientific name: Ascaris suum; NCBI TaxID: 6253;
ModificationList	sulfated residue; amidated residue; 2-pyrrolidone-5-carboxylic acid (Glu); 2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-17 09:38:38	ID requested
1	2023-07-26 07:03:53	announced
2	2023-11-14 06:44:25	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:58:02	announced	2024-10-22: Updated project metadata.

10.1371/JOURNAL.PPAT.1011508;

submitter keyword: Peptidomics, Helminths,Antimicrobial Peptides

Prof Angela Mousley
contact affiliation	Microbes & Pathogen Biology, The Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom
contact email	A.Mousley@qub.ac.uk
lab head
Darrin McKenzie
contact affiliation	Queen's University Belfast
contact email	dmckenzie02@qub.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042293

PRIDE project URI

• PRIDE
  1. PXD042293
     1. Label: PRIDE project
     2. Name: Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire