PXD042269

PXD042269 is an original dataset announced via ProteomeXchange.

Title	Impact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles
Description	The asialoglycoprotein receptor (ASGPR) and the mannose receptor 1 (MRC1) are C-type lectins that identify and remove glycoproteins from circulation. ASGPR recognizes terminal galactose and N-acetylgalactosamine, whereas MRC1 recognizes terminal mannose, fucose, and N-acetylglucosamine. The effects of ASGPR and MRC1 deficiency on the N-glycosylation of individual circulating proteins have been studied. However, the impact on the homeostasis of the major plasma glycoproteins is debated and their glycosylation has not been mapped with high molecular resolution in this context. Therefore, we evaluated the total plasma N-glycome and plasma proteome of ASGR1 and MRC1 deficient mice.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:11:41.203.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giangiacomo Beretta
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-16 11:43:53	ID requested
1	2023-10-24 13:20:12	announced
⏵ 2	2023-11-14 09:11:47	announced	2023-11-14: Updated project metadata.

Svecla M, Nour J, Bladergroen MR, Nicolardi S, Zhang T, Beretta G, Wuhrer M, Norata GD, Falck D, Impact of Asialoglycoprotein Receptor and Mannose Receptor Deficiency on Murine Plasma N-glycome Profiles. Mol Cell Proteomics, 22(9):100615(2023) [pubmed]

submitter keyword: Asialoglycoprotein receptor, Glycomics, Clearance, Proteomics, Mannose receptor

Giuseppe Danilo Norata
contact affiliation	Department of Pharmacological and Biomolecular Sciences, University of MIlan
contact email	danilo.norata@unimi.it
lab head
Giangiacomo Beretta
contact affiliation	Department of environmental science and policy
contact email	giangiacomo.beretta@unimi.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD042269

PRIDE project URI

• PRIDE
  1. PXD042269
     1. Label: PRIDE project
     2. Name: Impact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles