PXD042249 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia |
Description | Infant and adult MLL-rearranged (MLLr) leukemia represents a disease with few treatment options and a dismal prognosis. Here, we present an in-depth proteomic characterization of in utero-initiated and adult-onset MLLr leukemia in a mouse model of MLL-ENL-mediated leukemogenesis. We characterize early proteomic events of MLL-ENL-mediated transformation in fetal and adult progenitors. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:35:01.187.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sudip Ghosh |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-05-15 23:50:07 | ID requested | |
1 | 2024-04-02 03:00:16 | announced | |
⏵ 2 | 2024-10-22 06:35:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
Jassinskaja M, Ghosh S, Watral J, Davoudi M, Claesson Stern M, Daher U, Eldeeb M, Zhang Q, Bryder D, Hansson J, A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia. Leukemia, 38(5):1115-1130(2024) [pubmed] |
10.1038/s41375-024-02235-5; |
Keyword List
submitter keyword: Adult hematopoietic progenitor, TMTpro,MLL-rearranged leukemia, Fetal hematopoietic progenitor |
Contact List
Dr. Jenny Hansson |
contact affiliation | Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University |
contact email | jenny.hansson@med.lu.se |
lab head | |
Sudip Ghosh |
contact affiliation | Proteomic Hematology, Department of Experimental Medical Science, Lund Stem Cell Center, Lund University |
contact email | sudip.ghosh@med.lu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD042249 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042249
- Label: PRIDE project
- Name: Quantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia