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PXD042210

PXD042210 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of histone modifications present on nucleosomes bound by INO80 complex
DescriptionThe INO80 complex is a chromatin remodeler that regulates DNA replication, repair, and transcription. Although the INO80 complex plays a crucial role in various chromatin-associated processes, the mechanism of its recruitment to specific genomic loci is not well understood. Here we used a native ChIP-MS approach to quantitatively profile modifications present on nucleosomes co-purified with INO80 from MNAse-digested HeLa chromatin.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:17:08.365.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndrey Tvardovskiy
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonomethylated residue; acetylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-14 15:45:29ID requested
12023-12-10 12:26:11announced
22024-04-29 08:02:54announced2024-04-29: Updated project metadata.
32024-10-22 06:17:09announced2024-10-22: Updated project metadata.
Publication List
Lukauskas S, Tvardovskiy A, Nguyen NV, Stadler M, Faull P, Ravnsborg T, Ö, zdemir Aygenli B, Dornauer S, Flynn H, Lindeboom RGH, Barth TK, Brockers K, Hauck SM, Vermeulen M, Snijders AP, M, ü, ller CL, DiMaggio PA, Jensen ON, Schneider R, Bartke T, Decoding chromatin states by proteomic profiling of nucleosome readers. Nature, 627(8004):671-679(2024) [pubmed]
10.1038/s41586-024-07141-5;
Keyword List
submitter keyword: native ChIP-ms, INO80,histone PTMs
Contact List
Till Bartke
contact affiliationInstitute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany
contact emailtill.bartke@helmholtz-muenchen.de
lab head
Andrey Tvardovskiy
contact affiliationInstitute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany
contact emailtvardovsky.a@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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