PXD042092

PXD042092 is an original dataset announced via ProteomeXchange.

Title	Influence of generational obesity on the visceral adipose proteome
Description	Obesity is a global health concern affecting over 650 million adults with a major contributor being an increased consumption of a high-fat diet. Maternal obesity often results in an increased risk of offspring developing obesity. In this study, we examined the effect of diet on visceral adipose in a pre-clinical model of generational diet-induced obesity that included maternal cohorts of C57BL/6 mice fed either a control diet (10% fat) or a high-fat diet (45% fat) and the resulting female offspring fed either diet. Using bottom-up proteomics on omental adipose tissue, differential protein expression was determined with the greatest difference resulting from the generational obese cohort. Differentially expressed proteins were involved in pathways related to cancer, inflammatory disease and immune response. Taken together, the results of this study provide molecular-level insight that will enable the development of more targeted, modifiable interventions that could be implemented pre-, during and post-pregnancy.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:47:10.608.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rebecca Whelan
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-09 10:15:27	ID requested
⏵ 1	2024-10-17 02:47:11	announced

10.3390/nu16183086;

Schuster-Little N, McCabe M, Nenninger K, Safavi-Sohi R, Whelan RJ, Hilliard TS, Generational Diet-Induced Obesity Remodels the Omental Adipose Proteome in Female Mice. Nutrients, 16(18):(2024) [pubmed]

submitter keyword: proteomics, suspension trapping, generational obesity, omental tissue, adipose tissue, mouse,diet, S-Trap

Rebecca Whelan
contact affiliation	Department of Chemistry, University of Kansas, Lawrence, KS, United States
contact email	rwhelan1@ku.edu
lab head
Rebecca Whelan
contact affiliation	Department of Chemistry, University of Kansas
contact email	rwhelan1@ku.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD042092

PRIDE project URI

• PRIDE
  1. PXD042092
     1. Label: PRIDE project
     2. Name: Influence of generational obesity on the visceral adipose proteome