PXD042073

PXD042073 is an original dataset announced via ProteomeXchange.

Title	Mechanism of TP53 and RB1 inactivation-induced neuroendocrine phenotype transformation in TKI-resistant lung adenocarcinoma
Description	In order to study the mechanism of co-inactivation of RB1 and TP53 in the transformation of lung adenocarcinoma to small cell lung cancer, we established the NCI-H1975 cell line with RB1 knockdown.NCI-H1975 cells were cultured and infected with lentivirus expressing RB1-shRNA (n=3) or pLKO.1-shRNA (n=3), We then performed transcriptome sequencing (RNA-seq) on the above cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:41.977.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ying Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-08 20:42:31	ID requested
1	2023-08-20 01:10:26	announced
⏵ 2	2023-11-14 09:04:44	announced	2023-11-14: Updated project metadata.

Zhang Y, Chen Q, Huang T, Zhu D, Lu Y, Bioinformatics-based screening of key genes for transformation of tyrosine kinase inhibitor-resistant lung adenocarcinoma to small cell lung cancer. Front Med (Lausanne), 10():1203461(2023) [pubmed]

submitter keyword: Transformation,SCLC, NOTCH, TKI therapy resistance, LUAD

Yuanzhi Lu
contact affiliation	Department of Clinical Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China
contact email	yuanzhi.lu@jnu.edu.cn
lab head
Ying Zhang
contact affiliation	Jinan University First Affiliated Hospital
contact email	sunday12@stu2020.jnu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD042073

PRIDE project URI

• PRIDE
  1. PXD042073
     1. Label: PRIDE project
     2. Name: Mechanism of TP53 and RB1 inactivation-induced neuroendocrine phenotype transformation in TKI-resistant lung adenocarcinoma