PXD042055

PXD042055 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comparative Proteomics Reveals the Mechanism of Myocardial Adaptation to Chronic Hypoxic Injury
Description	Congenital heart disease is a congenital defect with a very high morbidity and mortality rate, of which Cyanotic Congenital Heart Disease (CCHD) is the most severe type.Due to the special anatomical changes of CCHD, the blood of the right ventricle cannot enter the pulmonary capillaries for full oxygenation, directly flows into the left ventricle and further flows into the systemic circulation, resulting in long-term hypoxia.Therefore, the study of the injury mechanism of cardiomyocytes under chronic hypoxia may provide a new treatment strategy for patients with cyanotic coronary heart disease.Mouse cardiomyocytes(CMCs) were treated with hypoxia for different periods of time (oh, 24h, 48h and 72h, respectively), followed by label free proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:46:32.103.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Miao Huang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-08 01:29:29	ID requested
1	2024-06-22 08:32:56	announced
⏵ 2	2024-10-22 06:46:36	announced	2024-10-22: Updated project metadata.

Publication List

10.1371/journal.pone.0305571;
Chen H, Yu S, Zhang X, Gao Y, Wang H, Li Y, He D, Jia W, Comparative proteomics reveals that fatty acid metabolism is involved in myocardial adaptation to chronic hypoxic injury. PLoS One, 19(6):e0305571(2024) [pubmed]

10.1371/journal.pone.0305571;

Chen H, Yu S, Zhang X, Gao Y, Wang H, Li Y, He D, Jia W, Comparative proteomics reveals that fatty acid metabolism is involved in myocardial adaptation to chronic hypoxic injury. PLoS One, 19(6):e0305571(2024) [pubmed]

Keyword List

submitter keyword: Cyanotic Congenital Heart Disease, Chronic Hypoxia, Proteomics, Mechanism, Cardiomyocyte

submitter keyword: Cyanotic Congenital Heart Disease, Chronic Hypoxia, Proteomics, Mechanism, Cardiomyocyte

Contact List

Weikun Jia
contact affiliation	Department of cardiothoracic surgery, the First Affiliated Hospital of Chengdu Medical College
contact email	wk_jia315@163.com
lab head
Miao Huang
contact affiliation	Mhelix.Co.,Ltd
contact email	dengjianhm@mhelix.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD042055
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD042055

PRIDE project URI

Repository Record List

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