PXD042033

PXD042033 is an original dataset announced via ProteomeXchange.

Title	iTRAQ-based quantitative proteomic profiling of Natranaerobius thermophilus in response to salinity stress
Description	Natranaerobius thermophilus is a unique extremophilic microorganism that exhibits remarkable adaptability and selectivity to the complex extreme environment characterized by high salt, high alkalinity, high temperature, and anaerobic conditions. However, the regulatory mechanisms of genes and proteins involved in the adaptation strategies of N. thermophilus to saline-alkaline-hot extreme environments remain poorly understood. In this project, we aim to study the adaptive strategies of N. thermophilus under different salt, alkaline, and thermal conditions using the TMT/iTRAQ-based quantitative proteomics approach. This includes investigating long-term adaptations and short-term regulatory responses to varying levels of salinity, alkalinity, and temperature. Additionally, we will explore the comprehensive adaptation mechanisms of N. thermophilus under multiple extreme conditions. This research will enhance our understanding of the intricate regulatory systems employed by extremophilic microorganisms and provide new insights into pushing the boundaries of life. The outcomes of this project will contribute significantly to our understanding of the fundamental principles underlying biological adaptability in extreme environments. By uncovering the adaptation strategies of N. thermophilus, this research will serve as a valuable reference for studying other extremophilic microorganisms and provide a theoretical basis for the development of biotechnological applications to cope with extreme environments. The results of this project will make important contributions to the deeper understanding of the adaptive mechanisms of extremophilic microorganisms and the diversity of life.
HostingRepository	iProX
AnnounceDate	2024-01-27
AnnouncementXML	Submission_2025-06-13_00:13:02.573.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qinghua Xing
SpeciesList	scientific name: Natranaerobius thermophilus JW/NM-WN-LF; NCBI TaxID: 457570;
ModificationList	iTRAQ4plex reporter+balance reagent acylated residue
Instrument	Q Exactive; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-05 21:48:56	ID requested
1	2024-01-03 20:01:34	announced
⏵ 2	2025-06-13 00:13:03	announced	2025-06-13: Add Publication.

Xing Q, Zhang S, Tao X, Mesbah NM, Mao X, Wang H, Wiegel J, Zhao B, . Appl Environ Microbiol, 90(5):e0014524(2024) [pubmed]

submitter keyword: Natranaerobius thermophilus, salinity stress, iTRAQ, proteomic

Baisuo Zhao
contact affiliation	Graduate School of Chinese Academy of Agriculture
contact email	bszhao@163.com
lab head
Qinghua Xing
contact affiliation	Graduate School of Chinese Academy of Agriculture
contact email	xingqinghua7777@163.com
dataset submitter

iProX dataset URI