PXD042026 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis |
Description | Individuals with Alzheimer Disease with psychotic symptoms (AD+P) experience more rapid cognitive and functional decline, and have reduced indices of synaptic integrity, relative to those without psychosis (AD-P). We hypothesized the postsynaptic density (PSD) proteome is altered in AD+P relative to AD-P, and that this proteomic signature could be used to nominate novel pharmacotherapies. METHODS: Liquid-Chromatography/Mass Spectrometry analysis of PSDs from dorsolateral prefrontal cortex of AD+P, AD-P and cognitively normal elderly subjects. RESULTS: The PSD proteome signature of AD+P was characterized by lower levels of a network of kinases, proteins regulating Rho GTPases, and proteins regulating the actin cytoskeleton. Potential novel therapies identified included the C-C Motif Chemokine Receptor 5 inhibitor, maraviroc. DISCUSSION: AD+P is characterized by broad changes in the PSD proteome in prefrontal cortex. Further testing of potential therapies for their ability to reverse these changes and protect against psychotic-like behaviors in model systems is warranted. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:01:19.433.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD042026 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Matthew MacDonald |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-05-05 10:11:35 | ID requested | |
1 | 2023-06-19 02:45:41 | announced | |
⏵ 2 | 2023-11-14 09:01:57 | announced | 2023-11-14: Updated project metadata. |
Publication List
Krivinko JM, DeChellis-Marks MR, Zeng L, Fan P, Lopez OL, Ding Y, Wang L, Kofler J, MacDonald ML, Sweet RA, Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease. Commun Biol, 6(1):598(2023) [pubmed] |
10.6019/PXD042026; |
Keyword List
submitter keyword: Alzheimer’s Disease |
Psychosis |
Post-synaptic Density |
Proteomics: Systems Pharmacology |
Contact List
Matthew MacDonald |
contact affiliation | University at Pittsbrugh Department of Psychiatry |
contact email | mlmacdonald@gmail.com |
lab head | |
Matthew MacDonald |
contact affiliation | University of Pittsburgh |
contact email | mlmacdonald@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD042026
- Label: PRIDE project
- Name: Targeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis