PXD042025

PXD042025 is an original dataset announced via ProteomeXchange.

Title	Targeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis
Description	Individuals with Alzheimer Disease who develop psychotic symptoms (AD+P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD+P relative to AD-P, analyzing PSDs from dorsolateral prefrontal cortex of AD+P, AD-P, and a reference group of cognitively normal elderly subjects. The PSD proteome of AD+P showed a global shift towards lower levels of all proteins relative to AD-P, enriched for kinases, proteins regulating Rho GTPases, and other regulators of the actin cytoskeleton. We computationally identified potential novel therapies predicted to reverse the PSD protein signature of AD+P. Five days of administration of one of these drugs, the C-C Motif Chemokine Receptor 5 inhibitor, maraviroc, led to a net reversal of the PSD protein signature in adult mice, nominating it as a novel potential treatment for AD+P.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:01:18.553.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD042025
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew MacDonald
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-05 09:53:19	ID requested
1	2023-06-19 03:47:15	announced
⏵ 2	2023-11-14 09:01:27	announced	2023-11-14: Updated project metadata.

Krivinko JM, DeChellis-Marks MR, Zeng L, Fan P, Lopez OL, Ding Y, Wang L, Kofler J, MacDonald ML, Sweet RA, Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease. Commun Biol, 6(1):598(2023) [pubmed]

10.6019/PXD042025;

submitter keyword: Human, Brain, Alzheimer Disease with Psychosis

Matthew L MacDonald
contact affiliation	Univeristy of Pittsbrugh
contact email	mlmacdonald@gmail.com
lab head
Matthew MacDonald
contact affiliation	University of Pittsburgh
contact email	mlmacdonald@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD042025

PRIDE project URI

• PRIDE
  1. PXD042025
     1. Label: PRIDE project
     2. Name: Targeting the Post-Synaptic Proteome in Alzheimer Disease with Psychosis