PXD041987

PXD041987 is an original dataset announced via ProteomeXchange.

Title	Proteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A
Description	We analyzed the total proteome of group 2 innate lymphoid cells (ILC2s) after different stimulation with interleukin-33 (IL-33), a cytokine playing a critical role in human asthma, and TL1A, a TNF-family cytokine also known to activate ILC2s. Upon combined stimulation with IL-33 plus TL1A, we show that lung ILC2s produce high amounts of IL-9 and acquire a transient ‘ILC9’ phenotype. This phenotype is characterized by simultaneous production of large amounts of type 2 cytokines (IL-5, IL-13 and IL-9), induction of the IL-2 receptor CD25 (Il2ra), and of the transcription factors IRF4, JunB and BATF, that form immune-specific complexes known to induce IL-9 expression.
HostingRepository	PRIDE
AnnounceDate	2024-03-05
AnnouncementXML	Submission_2024-03-05_10:07:09.402.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anne Gonzalez de Peredo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap Velos; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-04 16:23:18	ID requested
⏵ 1	2024-03-05 10:07:09	announced

Dataset with its publication pending

submitter keyword: TL1A, cytokine, IL33,group 2 innate lymphoid cells, ILC2, whole cell lysate, allergic inflammation, type 2 response, proteome, alarmin

Anne Gonzalez de Peredo
contact affiliation	Institute of Pharmacology and Structural Biology, CNRS, Toulouse
contact email	gonzalez@ipbs.fr
lab head
Anne Gonzalez de Peredo
contact affiliation	CNRS/IPBS
contact email	gonzalez@ipbs.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041987
     1. Label: PRIDE project
     2. Name: Proteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A