PXD041891

PXD041891 is an original dataset announced via ProteomeXchange.

Title	Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
Description	Prednisone is anti-inflammatory glucocorticoid (GC), and GC-based therapy is most used combination chemotherapy for treating aggressive B-cell lymphomas. However, there are still gaps in our understanding of specific mechanism of GC’s action for its cytotoxicity. By performing multi-omics approaches, we identified new GR targets and how these targets control the b-cell receptor signaling networks, providing a mechanistic framework upon which to base combination therapies.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:38:00.741.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jaewoo Choi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitinylated lysine; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-30 06:15:06	ID requested
1	2024-05-02 10:30:02	announced
⏵ 2	2024-10-22 06:38:01	announced	2024-10-22: Updated project metadata.

10.1016/J.CCELL.2024.04.007;

submitter keyword: lymphoma,glucocorticoid receptor (GR), BCR signaling, B cells

Louis M.
contact affiliation	Lymphoid Malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, Maryland
contact email	lstaudt@mail.nih.gov
lab head
Jaewoo Choi
contact affiliation	NIH/NCI
contact email	jaewoo.choi@nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD041891

PRIDE project URI

• PRIDE
  1. PXD041891
     1. Label: PRIDE project
     2. Name: Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas