PXD041806

PXD041806 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice
Description	This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of musculo-skeletal system as well as skeletal muscle atrophy and osteoporosis occurring on the ground by searching serum, bone and skeletal muscle proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of gestrocnemius muscles from male C57BL/6J mouse (microgravity and artificial 1-g [n=6, respectively]) were carried out tryptic digestion followed by LC-MS/MS analysis (DDA). The obtained results were searched against UniProt DB by Mascot, and the identified peptides were filtered at 1% FDR threshold by searching against the decoy DB.
HostingRepository	jPOST
AnnounceDate	2024-02-01
AnnouncementXML	Submission_2024-02-21_23:31:15.323.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yayoi Kimura
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	unknown modification; L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine; N6-carbamoyl-L-lysine; alpha-aminocarbamoylated residue; Acetyl
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-25 19:09:20	ID requested
1	2024-01-31 17:32:42	announced
⏵ 2	2024-02-21 23:31:16	announced	2024-02-22: Updated PubMed.

Publication List

Ohira T, Ino Y, Kawao N, Mizukami Y, Okada K, Matsuo O, Hirano H, Kimura Y, Kaji H, Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice. J Appl Physiol (1985), 136(3):643-658(2024) [pubmed]

Ohira T, Ino Y, Kawao N, Mizukami Y, Okada K, Matsuo O, Hirano H, Kimura Y, Kaji H, Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice. J Appl Physiol (1985), 136(3):643-658(2024) [pubmed]

Keyword List

submitter keyword: mouse, gastrocnemius muscle, spaceflight, microgravity

submitter keyword: mouse, gastrocnemius muscle, spaceflight, microgravity

Contact List

Yayoi Kimura
lab head
Yayoi Kimura
contact affiliation	Yokohama City University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002136/