PXD041738

PXD041738 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of gravity-responsive proteins in the femur of spaceflight mice using a quantitative proteomic approach
Description	This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Utilizing proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as osteoporosis occurring on the ground by searching serum, and skeletal muscle and bone (femoral diaphysis, mandible) proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of C57BL/6J space flown mouse (micro-G and artificial 1-G [n = 5/group, in femoral diaphysis and n = 6/group in mandible]) were carried out tryptic digestion followed by LC-MS/MS analysis (DIA). The obtained results were analyzed using Spectronaut Pulsar X against the mouse-bone spectral library for identification and quantification of proteins.
HostingRepository	jPOST
AnnounceDate	2023-08-01
AnnouncementXML	Submission_2023-08-01_02:20:08.408.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yayoi Kimura
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	unknown modification; L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine; N6-carbamoyl-L-lysine; alpha-aminocarbamoylated residue; alpha-amino acetylated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-22 16:13:40	ID requested
⏵ 1	2023-08-01 02:20:09	announced

Publication List

Egashira K, Ino Y, Nakai Y, Ohira T, Akiyama T, Moriyama K, Yamamoto Y, Kimura M, Ryo A, Saito T, Inaba Y, Hirano H, Kumagai K, Kimura Y, Identification of gravity-responsive proteins in the femur of spaceflight mice using a quantitative proteomic approach. J Proteomics, 288():104976(2023) [pubmed]

Egashira K, Ino Y, Nakai Y, Ohira T, Akiyama T, Moriyama K, Yamamoto Y, Kimura M, Ryo A, Saito T, Inaba Y, Hirano H, Kumagai K, Kimura Y, Identification of gravity-responsive proteins in the femur of spaceflight mice using a quantitative proteomic approach. J Proteomics, 288():104976(2023) [pubmed]

Keyword List

submitter keyword: Mouse, femur, mandible, microgravity exposure, Kibo project, medical Proteomics

submitter keyword: Mouse, femur, mandible, microgravity exposure, Kibo project, medical Proteomics

Contact List

Yayoi Kimura
lab head
Yayoi Kimura
contact affiliation	Yokohama City University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002135/