PXD041709 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia gene intraflagellar transport homolog 88 in Alzheimer's disease |
Description | A proteomic analysis of synaptic compartments obtained from septal-projecting hippocampal neurons revealed the formation of dystrophic neurites and synaptic loss at axon terminals as a result of the accumulation of numerous vesicles. Subsequent analysis also showed that toxic amyloid-β oligomers in the vicinity of dystrophic axons affected primary cilia, vesicle endocytosis, and neuronal exocytosis. The proteomic analysis of extracellular vesicles in presynaptic terminals confirmed that abnormal vesicle-mediated transport and exocytosis led to the accumulation of amyloid-β with extracellular vesicles at axon terminals. Further investigation showed that knockdown of the intraflagellar transport homolog 88 gene, which is essential for primary ciliogenesis in hippocampal neurons, led to an increase in amyloid-β uptake, leading to their accumulation with other synaptic vesicles at axon terminals. |
HostingRepository | PRIDE |
AnnounceDate | 2023-05-17 |
AnnouncementXML | Submission_2023-05-16_17:20:29.529.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | JaemyungJang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-21 01:09:45 | ID requested | |
⏵ 1 | 2023-05-16 17:20:29 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: primary cilia, extracellular vesicles, intraflagellar transport homolog 88, dystrophic axons |
Contact List
YoungshikChoe |
contact affiliation | Korea Brain Research Institute, Daegu, 41062, South Korea |
contact email | dallarae@gmail.com |
lab head | |
JaemyungJang |
contact affiliation | Korea Brain Research Institute |
contact email | piloter2@kbri.re.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD041709 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041709
- Label: PRIDE project
- Name: Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia gene intraflagellar transport homolog 88 in Alzheimer's disease