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PXD041709

PXD041709 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAbnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia gene intraflagellar transport homolog 88 in Alzheimer's disease
DescriptionA proteomic analysis of synaptic compartments obtained from septal-projecting hippocampal neurons revealed the formation of dystrophic neurites and synaptic loss at axon terminals as a result of the accumulation of numerous vesicles. Subsequent analysis also showed that toxic amyloid-β oligomers in the vicinity of dystrophic axons affected primary cilia, vesicle endocytosis, and neuronal exocytosis. The proteomic analysis of extracellular vesicles in presynaptic terminals confirmed that abnormal vesicle-mediated transport and exocytosis led to the accumulation of amyloid-β with extracellular vesicles at axon terminals. Further investigation showed that knockdown of the intraflagellar transport homolog 88 gene, which is essential for primary ciliogenesis in hippocampal neurons, led to an increase in amyloid-β uptake, leading to their accumulation with other synaptic vesicles at axon terminals.
HostingRepositoryPRIDE
AnnounceDate2023-05-17
AnnouncementXMLSubmission_2023-05-16_17:20:29.529.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJaemyungJang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-21 01:09:45ID requested
12023-05-16 17:20:29announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: primary cilia, extracellular vesicles, intraflagellar transport homolog 88, dystrophic axons
Contact List
YoungshikChoe
contact affiliationKorea Brain Research Institute, Daegu, 41062, South Korea
contact emaildallarae@gmail.com
lab head
JaemyungJang
contact affiliationKorea Brain Research Institute
contact emailpiloter2@kbri.re.kr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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