PXD041668

PXD041668 is an original dataset announced via ProteomeXchange.

Title	Proteome alterations in the lung of Beagle dogs during the lung migration stage of Toxocara canis infection
Description	Background: Toxocara canis is a prevalent helminth, which threatens millions of people worldwide with a predilection for pediatric and adolescent populations in impoverished communities. Exploring the invasion and developmental mechanisms associated with T. canis infection in its definitive hosts will help to better control and eliminate the effects of toxocariasis. Methods: To investigate the molecular mechanism of Beagle dogs' response to T. canis infection, proteomic alterations in the lung of Beagle puppies were systematically analyzed by data-independent acquisition (DIA)-based quantitative proteomic technology at 96 h post-infection (hpi). Proteins with P-values < 0.05 and fold change> 1.5 or  <0.67 were considered as proteins with differential abundance (PDAs). Results: A total of 28 down-regulated PDAs and 407 up-regulated PDAs were identified at 96 hpi, including RhoC, TM4SFs and LPCAT1, which could be associated with the maintenance and repair of lung homeostasis. Gene Ontology (GO) annotation and K
HostingRepository	iProX
AnnounceDate	2023-04-20
AnnouncementXML	Submission_2024-06-06_00:45:46.758.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenbin Zheng
SpeciesList	scientific name: Canis lupus familiaris; NCBI TaxID: 9615;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-19 21:53:43	ID requested
⏵ 1	2024-06-06 00:45:47	announced

Zheng WB, Qiu HJ, Xiao HD, Zou Y, Zhu XQ, Proteomic change in the upper lobe of the left lung of Beagle dogs at the lung migration stage of Toxocara canis infection. Parasit Vectors, 17(1):210(2024) [pubmed]

submitter keyword: Proteome alterations, lung, Beagle dog

Xingquan Zhu
contact affiliation	Shanxi Agricultural University
contact email	xingquanzhu1@hotmail.com
lab head
Wenbin Zheng
contact affiliation	Shanxi Agricultural University
contact email	wenbinzheng1@126.com
dataset submitter

iProX dataset URI