PXD041665

PXD041665 is an original dataset announced via ProteomeXchange.

Title	Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in in mice and humans
Description	The meninges of the brain are an important component of neuroinflammatory response. Diverse immune cells move from the calvaria marrow into the dura mater via recently discovered skull-meninges connections (SMCs). However, how the calvaria bone marrow is different from the other bones and whether and how it contributes to human diseases remain unknown. Using multi-omics approaches and whole mouse transparency we reveal that bone marrow cells are highly heterogeneous across the mouse body. The mouse calvaria and the human skull harbors the most distinct molecular signature with hundreds of differentially expressed genes and proteins when compared to other bones. Our study indicates that the calvaria is more than a physical barrier, and its immune cells may present new ways to control brain pathologies.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:49:26.258.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Saketh Kapoor
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF SCP

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-19 17:58:10	ID requested
1	2023-07-29 09:06:46	announced
⏵ 2	2023-11-14 06:49:26	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Calvaria, Meninges, Brain, timsTOF SCP, Proteomics

Prof. Dr.
contact affiliation	Institute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München Ingolstädter Landstraße 1 85764 Neuherberg Germany
contact email	ali.ertuerk@med.uni-muenchen.de
lab head
Saketh Kapoor
contact affiliation	Dr. Saketh Kapoor, Ph.D. Mass Spectrometry Unit In-Charge Institute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München Ingolstädter Landstraße 1 85764 Neuherberg Germany +49 15129916548 saketh.kapoor@helmholtz-munich.de http://erturk-lab.com/team/
contact email	saketh.kapoor@helmholtz-munich.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD041665

PRIDE project URI

• PRIDE
  1. PXD041665
     1. Label: PRIDE project
     2. Name: Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in in mice and humans