PXD041645

PXD041645 is an original dataset announced via ProteomeXchange.

Title	The effect of Y145C mutation in AHCY-1 on the total proteome of young adults C.elegans
Description	Supplementation with S-adenosylhomocysteine (SAH) extends the lifespan of model organisms. To explore the impact of SAH on aging, we generated a Caenorhabditis elegans model with increased SAH levels through pathogenic mutation in the S-adenosylhomocysteine hydrolase (AHCY-1), which impairs SAH hydrolysis to adenosine and homocysteine. This submission contains results of the quantitative (TMT) measurements of the proteins in whole worm extracts originated from AHCY-1 Y143C mutant (equivalent to the human pathogenic variant) and control worms.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:56:35.358.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Remigiusz Serwa
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-19 04:19:46	ID requested
1	2023-09-29 06:46:07	announced
⏵ 2	2023-11-14 08:56:35	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Caenorhabditis elegans, AHCY-1 Y145C mutant, S-adenosylhomocysteine, S-adenosylhomocysteine hydrolase, aging

Wojciech Pokrzywa
contact affiliation	Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Poland
contact email	wpokrzywa@iimcb.gov.pl
lab head
Remigiusz Serwa
contact affiliation	The International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences
contact email	r.serwa@imol.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD041645

PRIDE project URI

• PRIDE
  1. PXD041645
     1. Label: PRIDE project
     2. Name: The effect of Y145C mutation in AHCY-1 on the total proteome of young adults C.elegans