PXD041643

PXD041643 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomics in pig models of pulmonary hypertension
Description	The objective of this project is to identify relevant mechanisms associated to maladaptive right ventricular hypertrophy (RV) in pulmonary hypertension (PH), beyond pressure overload. For that, we analyzed plasma samples from PH pig models by high-throughput proteomics. Four different experimental models in 48 Yucatan pigs were developed: chronic postcapillary PH by pulmonary vein banding (M1); chronic PH by aorto-pulmonary shunting (M2); RV pressure overload by pulmonary artery banding, thus without PH (M3); and a sham procedure (M0). Animals were evaluated at months 1, and 8 after surgery with right heart catheterization, cardiac magnetic resonance (CMR), and blood sampling, and myocardial tissue was analyzed with histology and molecular biology. Unbiased proteomic and metabolomic analyses were performed and compared among experimental groups and related to the severity of PH and RV dysfunction through integrative interactome networking.
HostingRepository	PRIDE
AnnounceDate	2025-01-21
AnnouncementXML	Submission_2025-01-20_17:14:49.839.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Inmaculada Jorge
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	methylthiolated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-19 02:40:29	ID requested
⏵ 1	2025-01-20 17:14:50	announced

10.1007/s00395-024-01041-5;

Garc, í, a-Lunar I, Jorge I, S, á, iz J, Solanes N, Dantas AP, Rodr, í, guez-Arias JJ, Ascaso M, Gal, á, n-Arriola C, Jim, é, nez FR, Sandoval E, Nuche J, Moran-Garrido M, Camafeita E, Rigol M, S, á, nchez-Gonzalez J, Fuster V, V, á, zquez J, Barbas C, Ib, á, ñ, ez B, Pereda D, Garc, í, a-, Á, lvarez A, Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation. Basic Res Cardiol, 119(3):419-433(2024) [pubmed]

submitter keyword: proteomics, plasma,Pig

Jesús Vázquez Cobos
contact affiliation	Centro Nacional de Investigaciones Cardiovasculares (CNIC). CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
contact email	jvazquez@cnic.es
lab head
Inmaculada Jorge
contact affiliation	Cardiovascular Proteomics Lad. Spanish National Center for Cardiovascular Research (CNIC). Madrid.
contact email	ijorge@cnic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD041643

PRIDE project URI

• PRIDE
  1. PXD041643
     1. Label: PRIDE project
     2. Name: Plasma proteomics in pig models of pulmonary hypertension