PXD041614

PXD041614 is an original dataset announced via ProteomeXchange.

Title	Restoration of CPEB4 Prevents Muscle Stem Cell Senescence during Aging
Description	Muscle stem cells (MuSCs) are required for muscle regeneration. In resting muscles, MuSCs are kept in quiescence. After injury, MuSCs undergo rapid activation, proliferation and differentiation to repair damaged muscles. Age-associated impairments in stem cell functions correlate with a decline in somatic tissue regeneration capacity during aging. However, the mechanisms underlying the molecular regulation of adult stem cell aging remain elusive. Here, we obtained quisecent MuSCs from young, old, geriatric mice for high resolution mass spectrometry Bruker timsTOF Pro. By comparison of young proteome to old MuSCs proteome or geriatric MuSC proteome, we identified the pathways that are differentially during aging.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:48:27.410.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041614
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Wenxin ZHANG
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-18 00:59:01	ID requested
1	2023-06-25 18:55:02	announced
⏵ 2	2023-11-14 06:48:27	announced	2023-11-14: Updated project metadata.

10.6019/PXD041614;

submitter keyword: Aging,Mouse, Proteome, Muscle stem cells, CPEB4

Tom Hiu Tung CHEUNG
contact affiliation	S H Ho Associate Professor of Life Science, Hong Kong University of Science and Technology, Hong Kong SAR, CHINA
contact email	tcheung@ust.hk
lab head
Wenxin ZHANG
contact affiliation	HKUST
contact email	wzhangbn@connect.ust.hk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD041614

PRIDE project URI

• PRIDE
  1. PXD041614
     1. Label: PRIDE project
     2. Name: Restoration of CPEB4 Prevents Muscle Stem Cell Senescence during Aging