PXD041605

PXD041605 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	OGA-mediated protein glycosylation regulates pluripotency states in human embryonic stem cells
Description	In our previous study, we uncovered that OGA significantly elevated in naïve hESC. Therefore, we sought to investigate the effects of O-GlcNAc on hESC and the interconvert of both pluripotent states. Depletion of OGA, which results in global O-GlcNAcylation increased, would impair naïve hESC pluripotency but can promote naïve to primed hESC transition. In addition, we obtained the profiles of O-GlcNAcylated proteins in H9 primed hESC and H9-PXGL hESC via MS based-quantitative proteomics.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:54:12.784.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhiya Fan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dimethylated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-17 21:10:33	ID requested
1	2024-08-10 12:03:34	announced
⏵ 2	2024-10-22 06:54:13	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/j.stemcr.2024.05.009;
Liu Q, Chen C, Fan Z, Song H, Sha Y, Yu L, Wang Y, Qin W, Yi W, O-GlcNAcase regulates pluripotency states of human embryonic stem cells. Stem Cell Reports, 19(7):993-1009(2024) [pubmed]

10.1016/j.stemcr.2024.05.009;

Liu Q, Chen C, Fan Z, Song H, Sha Y, Yu L, Wang Y, Qin W, Yi W, O-GlcNAcase regulates pluripotency states of human embryonic stem cells. Stem Cell Reports, 19(7):993-1009(2024) [pubmed]

Keyword List

submitter keyword: human embryonic stem cells，OGA，O-GlcNAc

submitter keyword: human embryonic stem cells，OGA，O-GlcNAc

Contact List

Qin Weijie
contact affiliation	National Center for Protein Science, Beijing
contact email	aunp_dna@126.com
lab head
Zhiya Fan
contact affiliation	National Center for Protein Sciences (Beijing)
contact email	zyfan7@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD041605
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD041605

PRIDE project URI

Repository Record List

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