PXD041604

PXD041604 is an original dataset announced via ProteomeXchange.

Title	Tandem mass tag-based quantitative proteomic analysis reveals proteins involved in hemolytic hyperbilirubinemia-induced brain injury in rats
Description	Hemolytic hyperbilirubinemia-induced brain injury (HHIBI) can cause neonatal death, and survivors often have neurological sequelae, including irreversible motor sensitive and cognitive abnormalities. However, the underlying mechanisms remain elusive. By identifying differentially abundant proteins (DAPs), using proteomics, in the brain tissue of HHIBI rats, we aimed to identify the underlying molecular mechanisms of HHIBI. Tandem mass tag (TMT) labelling and LC-MS/MS were performed, and thereafter bioinformatics methods were used to characterize the molecular and functional signatures of HHIBI. In total, 7104 proteins were identified and 6848 were quantified. We detected 138 upregulated and 242 downregulated DAPs. Further, we found that the upregulated DAPs are involved in complement and coagulation cascade pathways. In addition, downregulated DAPs are mainly involved in DNA replication, mismatch repair, base excision repair, and cell cycle pathways. The Protein-Protein Interactions (PPI) network revealed tha
HostingRepository	iProX
AnnounceDate	2023-04-18
AnnouncementXML	Submission_2023-12-05_22:44:56.318.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinfu Zhou
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	TMT6plex reporter fragment
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-17 20:34:36	ID requested
1	2023-10-31 19:04:58	announced
⏵ 2	2023-12-05 22:44:57	announced	2023-12-06: Update publication information.

Zhou J, Lin X, Liao S, Li G, Tang J, Luo J, Zhang C, Wu S, Xu L, Li H, vivo and in vitro. Mol Med Rep, 28(6):(2023) [pubmed]

submitter keyword: Hemolytic hyperbilirubinemia, Brain injury, Proteomics, Bioinformatics analysis, DNA replication

Jinfu Zhou
contact affiliation	Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics
contact email	zhou811203@fjmu.edu.cn
lab head
Jinfu Zhou
contact affiliation	Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics
contact email	zhou811203@fjmu.edu.cn
dataset submitter

iProX dataset URI