PXD041579

PXD041579 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomics of BACE2 KO mice
Description	The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify substrates of the protease BACE2 in plasma of mice. Therefore, we analysed plasma from BACE2 KO, and WT controls. Inactivation of BACE2 inhibited shedding of VEGFR3/FLT4. Thus, sVEGFR3 represents a pharmacodynamic plasma marker for BACE2 activity in vivo.
HostingRepository	PRIDE
AnnounceDate	2024-06-27
AnnouncementXML	Submission_2024-06-27_09:11:06.188.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephan Mueller
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-17 04:24:10	ID requested
⏵ 1	2024-06-27 09:11:07	announced

10.1172/jci170550;

Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, A, ß, falg M, M, ü, ller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF, The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling. J Clin Invest, 134(16):(2024) [pubmed]

submitter keyword: BACE2, beta secretase, plasma, mouse

Stefan F. Lichtenthaler
contact affiliation	DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany
contact email	stefan.lichtenthaler@dzne.de
lab head
Stephan Mueller
contact affiliation	DZNE Munich Neuroproteomics
contact email	stephan.mueller@dzne.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD041579

PRIDE project URI

• PRIDE
  1. PXD041579
     1. Label: PRIDE project
     2. Name: Plasma proteomics of BACE2 KO mice