PXD041579
PXD041579 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma proteomics of BACE2 KO mice |
Description | The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify substrates of the protease BACE2 in plasma of mice. Therefore, we analysed plasma from BACE2 KO, and WT controls. Inactivation of BACE2 inhibited shedding of VEGFR3/FLT4. Thus, sVEGFR3 represents a pharmacodynamic plasma marker for BACE2 activity in vivo. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-27 |
AnnouncementXML | Submission_2024-06-27_09:11:06.188.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stephan Mueller |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-04-17 04:24:10 | ID requested | |
⏵ 1 | 2024-06-27 09:11:07 | announced |
Publication List
10.1172/jci170550; |
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, A, ß, falg M, M, ü, ller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF, The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling. J Clin Invest, 134(16):(2024) [pubmed] |
Keyword List
submitter keyword: BACE2, beta secretase, plasma, mouse |
Contact List
Stefan F. Lichtenthaler | |
---|---|
contact affiliation | DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany |
contact email | stefan.lichtenthaler@dzne.de |
lab head | |
Stephan Mueller | |
contact affiliation | DZNE Munich Neuroproteomics |
contact email | stephan.mueller@dzne.de |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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