PXD041548

PXD041548 is an original dataset announced via ProteomeXchange.

Title	PROTEOMIC PROFILE OF THE URINE OF BOTHROPIC ENVENOMING VICTIMS’ WHO DEVELOPED ACUTE KIDNEY INJURY
Description	Snakebite is a serious public health problem and is classified as a neglected tropical disease that affects approximately 2.7 million people worldwide and results in more than 138.000 deaths per year, the vast majority in tropical and subtropical countries. Brazil is among the six countries with the highest number of snakebite poisonings, 111,932 cases are reported annually, 86.7% of which are botropic accidents. Amazonas has high rates of snakebite cases, registering approximately 9,174 annual cases across the state. Bothrops atrox, whose venom triggers local and systemic effects in its victims, is responsible for about 80-90% of cases in the region. The effect of botropic venom can cause everything from local manifestations to systemic changes, with acute renal failure being one of the most important complications resulting from these poisonings with high rates of morbidity and mortality. Proteomic analysis has the potential to visualize molecular changes and can be a powerful tool in the prior identification of differential proteins associated with toxicity and severity or progression of a given disease. Urine is a less complex sample when compared to other biofluids and can be a useful tool in the identification of kidney disease biomarkers. Thus, this study aimed to characterize the protein profile in urine samples of patient’s victims of a botropic accident with clinical outcome of acute renal failure.
HostingRepository	PRIDE
AnnounceDate	2024-03-18
AnnouncementXML	Submission_2024-03-18_08:00:43.406.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Priscila Aquino
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-14 09:53:49	ID requested
⏵ 1	2024-03-18 08:00:43	announced

10.1371/JOURNAL.PNTD.0012072;

submitter keyword: Bothrops, Acute renal,Ophidian accidents, Proteomics, Amazonia

Priscila Aquino
contact affiliation	Laboratory Microbial Diversity of the Amazon with Importance for Health - DMAIS
contact email	priscila.aquino@fiocruz.br
lab head
Priscila Aquino
contact affiliation	FIOCRUZ-ILMD
contact email	proteomics_ilmd@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD041548

PRIDE project URI

• PRIDE
  1. PXD041548
     1. Label: PRIDE project
     2. Name: PROTEOMIC PROFILE OF THE URINE OF BOTHROPIC ENVENOMING VICTIMS’ WHO DEVELOPED ACUTE KIDNEY INJURY