PXD041535

PXD041535 is an original dataset announced via ProteomeXchange.

Title	Proteomics Study and Protein Biomarkers of Malignant Ventricular Arrhythmia in Acute Myocardial Infarction Patients
Description	Acute myocardial infarction (AMI) is one of the leading causes of death. It is particularly important to predict malignant ventricular arrhythmia (MVA) timely and accurately in patients with AMI. This study aimed to explore biomarkers and to reveal possible mechanisms of MVA in AMI for clinical diagnosis. Blood samples from 190 human subjects were collected to reveal the differentially expressed proteins (DEPs) in three comparisons (AMI/control, AMI+MVA/control, and AMI+MVA/AMI) in proteomics with bioinformatics analysis and validated in new cohorts. The diagnostic value of candidate DEPs predicting AMI+MVA was also evaluated by the receiver operating characteristic curve (ROC). A total of 8,365 peptides and 460 proteins from the LC-MS/MS analysis were identified with 90 in AMI/control, 94 in AMI+MVA/control, and 43 in AMI+MVA/AMI identified as DEPs. TGFBI level had notable decreasing trend in AMI+MVA (161.9 ± 19.0 ng/ml) compared with AMI (P<0.0001) or control (P<0.0001). vWF level in AMI+MVA patients was significantly higher than that in AMI patients (P<0.01) and control (P<0.0001). ROC analysis showed that TGFBI and vWF had the strong and potential value of predicting MVA in AMI. By constructing proteomics profile to identify the protein characteristics this study found that decreased TGFBI and increased vWF are the characteristics of proteins in the MVA patients with AMI. These findings provide new insight into the diagnosis and pathogenesis of the development of MVA. Further, decreased TGFBI and increased vWF are potential predicting biomarkers for diagnosis of MVA in AMI patients.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_12:56:53.098.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hai-Tao Hou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-14 04:06:37	ID requested
⏵ 1	2024-01-26 12:56:53	announced

Zhang JL, Hou HT, Song Y, Guo M, Liu XC, Yang Q, He GW, Proteomics study and protein biomarkers of malignant ventricular arrhythmia in acute myocardial infarction patients. Clin Transl Med, 13(11):e1435(2023) [pubmed]

10.1002/ctm2.1435;

submitter keyword: Acute myocardial infarction

malignant ventricular arrhythmia

proteomics

data independent acquisition

Hou Hai Tao
contact affiliation	The Institute of Cardiovascualr Diseases &Department of Cardiovascular surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Graduate School of Peking Union Medical College &Tianjin University, Tianjin, China
contact email	hhtpk007@163.com
lab head
Hai-Tao Hou
contact affiliation	Teda International Cardiovascular Hospital
contact email	hhtpk007@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041535
     1. Label: PRIDE project
     2. Name: Proteomics Study and Protein Biomarkers of Malignant Ventricular Arrhythmia in Acute Myocardial Infarction Patients