PXD041530

PXD041530 is an original dataset announced via ProteomeXchange.

Title	Proteomics of cardiac tissue of mice after sepsis model
Description	Dysregulated cardiac function after sepsis is common in intensive care unit (ICU) and known to predict poor long-term outcome and increase mortality. Effective therapeutic strategies are largely lacking. Moreover, the pathological feature and the molecular mechanism underlying cardiac dysfunction induced by sepsis remain unclear. Here, by performing echocardiograms on rodents after induction of polymicrobial sepsis with cecum ligation and puncture (CLP), we assessed the temporal dynamics of left ventricular ejection fraction (LVEF) and a serial of hemodynamics parameters on animals at different time point after CLP. Intriguingly, the mean LVEF is comparable in mice induced by CLP and sham, whereas survivors post CLP had stable LVEF and non-survivors had markedly fluctuated LVEF at early phase of CLP induction, suggesting LVEF away from normal range is highly associated with mortality. Consistent with clinical observations of depressed, preserved or hyperdynamic LVEF in septic patients from data compiled using our ICU cohort and from other studies, CLP-induced mice fall into three groups based on LVEF measured at 24 hours after surgery: high LVEF (HEF, LVEF>=90%), low LVEF (LEF, LVEF<65%), and normal LVEF (NEF, 65%=
HostingRepository	iProX
AnnounceDate	2023-04-14
AnnouncementXML	Submission_2023-10-26_19:06:48.930.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Desheng Qi
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-13 21:27:39	ID requested
1	2023-08-28 19:24:46	announced
⏵ 2	2023-10-26 19:06:49	announced	2023-10-27: Update publication information.

Zhang L, Qi D, Peng M, Meng B, Wang X, Zhang X, Zuo Z, Li L, Wang Z, Zou W, Hu Z, Qian Z, Decoding molecular signature on heart of septic mice with distinct left ventricular ejection fraction. iScience, 26(10):107825(2023) [pubmed]

submitter keyword: Sepsis induced myocardium dysfunction, Proteomics, Clinical subtype, Molecular subtype

Zhonghua Hu
contact affiliation	Xiangya Hospital, Central South University
contact email	huzhonghua@csu.edu.cn
lab head
Desheng Qi
contact affiliation	Xiangya Hospital, Central South University
contact email	qidesheng17@csu.edu.cn
dataset submitter

iProX dataset URI