PXD041495 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay |
Description | Cytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PABPC in vivo by deleting, depleting, overexpressing, or mutating the protein has led to conflicting models of PABPC's function. To specifically assess direct and indirect consequences of deleting PABPC, we generated and analyzed RNA-Seq, ribosome profiling, and mass spectrometry data from yeast cells lacking Pab1. |
HostingRepository | PRIDE |
AnnounceDate | 2023-06-09 |
AnnouncementXML | Submission_2023-06-09_13:26:24.855.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD041495 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | KotchaphornMangkalaphiban |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-12 11:34:48 | ID requested | |
⏵ 1 | 2023-06-09 13:26:25 | announced | |
Publication List
Keyword List
submitter keyword: poly(A)-binding protein, yeast, Saccharomyces cerevisiae, Pab1,LC-MSMS |
Contact List
AllanJacobson |
contact affiliation | Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA USA |
contact email | allan.jacobson@umassmed.edu |
lab head | |
KotchaphornMangkalaphiban |
contact affiliation | University of Massachusetts Chan Medical School |
contact email | kotchaphorn.mangkalaphiban@umassmed.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041495
- Label: PRIDE project
- Name: Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay