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PXD041495

PXD041495 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDirect and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay
DescriptionCytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PABPC in vivo by deleting, depleting, overexpressing, or mutating the protein has led to conflicting models of PABPC's function. To specifically assess direct and indirect consequences of deleting PABPC, we generated and analyzed RNA-Seq, ribosome profiling, and mass spectrometry data from yeast cells lacking Pab1.
HostingRepositoryPRIDE
AnnounceDate2023-06-09
AnnouncementXMLSubmission_2023-06-09_13:26:24.855.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD041495
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterKotchaphornMangkalaphiban
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-12 11:34:48ID requested
12023-06-09 13:26:25announced
Publication List
10.6019/PXD041495;
Keyword List
submitter keyword: poly(A)-binding protein, yeast, Saccharomyces cerevisiae, Pab1,LC-MSMS
Contact List
AllanJacobson
contact affiliationDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA USA
contact emailallan.jacobson@umassmed.edu
lab head
KotchaphornMangkalaphiban
contact affiliationUniversity of Massachusetts Chan Medical School
contact emailkotchaphorn.mangkalaphiban@umassmed.edu
dataset submitter
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Dataset FTP location
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