PXD041495

PXD041495 is an original dataset announced via ProteomeXchange.

Title	Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay
Description	Cytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PABPC in vivo by deleting, depleting, overexpressing, or mutating the protein has led to conflicting models of PABPC's function. To specifically assess direct and indirect consequences of deleting PABPC, we generated and analyzed RNA-Seq, ribosome profiling, and mass spectrometry data from yeast cells lacking Pab1.
HostingRepository	PRIDE
AnnounceDate	2023-06-09
AnnouncementXML	Submission_2023-06-09_13:26:24.855.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041495
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	KotchaphornMangkalaphiban
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-12 11:34:48	ID requested
⏵ 1	2023-06-09 13:26:25	announced

10.6019/PXD041495;

submitter keyword: poly(A)-binding protein, yeast, Saccharomyces cerevisiae, Pab1,LC-MSMS

AllanJacobson
contact affiliation	Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA USA
contact email	allan.jacobson@umassmed.edu
lab head
KotchaphornMangkalaphiban
contact affiliation	University of Massachusetts Chan Medical School
contact email	kotchaphorn.mangkalaphiban@umassmed.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD041495
     1. Label: PRIDE project
     2. Name: Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay