PXD041472

PXD041472 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of proteins bound with RPA194 at rDNA loci post radiation in breast cancer cells
Description	Following radiation damage, cells resume ribosome biogenesis for survival. We combined chromatin immunoprecipitation (ChIP) with mass spectrometry to identify key binding partners of RPA194 (the major subunit of RNA polI) at the rDNA loci in response to irradiation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:56:43.826.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD041472
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brandon Metge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-11 13:57:42	ID requested
1	2023-07-20 11:53:51	announced
2	2023-11-14 09:03:41	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:56:46	announced	2024-10-22: Updated project metadata.

Publication List

10.6019/PXD041472;
Metge BJ, Alsheikh HA, Chen D, Elhamamsy AR, Hinshaw DC, Chen BR, Sleckman BP, Samant RS, Shevde LA, Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy. NPJ Precis Oncol, 7(1):61(2023) [pubmed]
10.1038/s41698-023-00410-y;

10.6019/PXD041472;

Metge BJ, Alsheikh HA, Chen D, Elhamamsy AR, Hinshaw DC, Chen BR, Sleckman BP, Samant RS, Shevde LA, Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy. NPJ Precis Oncol, 7(1):61(2023) [pubmed]

10.1038/s41698-023-00410-y;

Keyword List

submitter keyword: Breast cancer, rDNA, RPA194, radiation,ChIP-MS, IR

submitter keyword: Breast cancer, rDNA, RPA194, radiation,ChIP-MS, IR

Contact List

Lalita Samant
contact affiliation	University of Alabama at Birmingham, Department of Pathology, Division MCP, O'Neal Comprehensive Cancer Center
contact email	lalitasamant@uabmc.edu
lab head
Brandon Metge
contact affiliation	University of Alabama at Birmingham
contact email	brandonmetge@uabmc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD041472
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD041472

PRIDE project URI

Repository Record List

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