PXD041440 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Using HDX-MS to study Rab and Ral covalently bound to MRTX1257 |
Description | Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-10 |
AnnouncementXML | Submission_2025-03-10_12:01:57.654.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | John Burke |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | impact HD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-04-10 14:48:34 | ID requested | |
⏵ 1 | 2025-03-10 12:01:58 | announced | |
Publication List
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM, Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell, 187(22):6379-6392.e17(2024) [pubmed] |
10.1016/j.cell.2024.08.017; |
Keyword List
submitter keyword: Rab,HDX-MS,Ral,HDX,Gtpase |
Contact List
John Burke |
contact affiliation | University of Victoria |
contact email | jeburke@uvic.ca |
lab head | |
John Burke |
contact affiliation | University of Victoria |
contact email | jeburke@uvic.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD041440 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD041440
- Label: PRIDE project
- Name: Using HDX-MS to study Rab and Ral covalently bound to MRTX1257