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PXD041440

PXD041440 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUsing HDX-MS to study Rab and Ral covalently bound to MRTX1257
DescriptionHere we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.
HostingRepositoryPRIDE
AnnounceDate2025-03-10
AnnouncementXMLSubmission_2025-03-10_12:01:57.654.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohn Burke
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrumentimpact HD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-10 14:48:34ID requested
12025-03-10 12:01:58announced
Publication List
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM, Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell, 187(22):6379-6392.e17(2024) [pubmed]
10.1016/j.cell.2024.08.017;
Keyword List
submitter keyword: Rab,HDX-MS,Ral,HDX,Gtpase
Contact List
John Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
lab head
John Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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