PXD041440

PXD041440 is an original dataset announced via ProteomeXchange.

Title	Using HDX-MS to study Rab and Ral covalently bound to MRTX1257
Description	Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.
HostingRepository	PRIDE
AnnounceDate	2025-03-10
AnnouncementXML	Submission_2025-03-10_12:01:57.654.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-10 14:48:34	ID requested
⏵ 1	2025-03-10 12:01:58	announced

Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM, Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell, 187(22):6379-6392.e17(2024) [pubmed]

10.1016/j.cell.2024.08.017;

submitter keyword: Rab,HDX-MS,Ral,HDX,Gtpase

John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD041440

PRIDE project URI

• PRIDE
  1. PXD041440
     1. Label: PRIDE project
     2. Name: Using HDX-MS to study Rab and Ral covalently bound to MRTX1257