PXD041418

PXD041418 is an original dataset announced via ProteomeXchange.

Title	A genetic deficiency screen in vivo reveals rescue mechanisms of mitochondrial dysfunction
Description	The mitochondrial network forms a central hub in cellular metabolism, adapting to a vast array of environmental and cellular signals to maintain cellular homeostasis. Derangements to this network can lead to mitochondrial diseases but are also increasingly recognised to be a contributing factor in common disorders including heart failure, neurodegeneration, cancer, or the natural ageing process. Despite its central importance, little is known how the cell responds to a mitochondrial dysfunction, contributing to our lack of affective treatment strategies. Here we performed an unbiased genetic deficiency screen in the fruit fly to identify mechanisms that can rescue a lethal mitochondrial dysfunction. After screening ~40% of the fly genome, we identified 10 genes from four distinct cellular pathways that rescued the mitochondrial dysfunction upon heterozygous deletion, resulting in viable adult flies. The data presented here includes proteomic analysis of larvae of control, mutant, and rescued lines.
HostingRepository	PRIDE
AnnounceDate	2024-12-01
AnnouncementXML	Submission_2024-12-01_09:04:38.084.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-09 11:42:10	ID requested
⏵ 1	2024-12-01 09:04:38	announced

Dataset with its publication pending

submitter keyword: mtDNA, autophagy,Mitochondria, Drosophila, insulin

Dr. Matthias Mann
contact affiliation	Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
contact email	mmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD041418

PRIDE project URI

• PRIDE
  1. PXD041418
     1. Label: PRIDE project
     2. Name: A genetic deficiency screen in vivo reveals rescue mechanisms of mitochondrial dysfunction