PXD041371
PXD041371 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of acetylation and lactylation reveals P2Y12 antagonist via EMT inhibiting human cervical cancer cells migration |
| Description | The potential risk of P2Y12 antagonists for cancer treatment is controversial. Here we show that PSB 0739, a P2Y12 antagonist inhibits human cervical cancer cells (Hela and SiHa) migration without modifying cell proliferation. We identify that the co-acetylation and lactylation of epithelial-mesenchymal transition (EMT)-related protein NCL, MYH9, CTTN, S100A6, and ALDOA revealed by proteomic analysis of posttranslational modifications (PTM), are responsible for the PSB0739-induced migration inhibition in human cervical cancer cells. Our data suggest that as one of P2Y12 antagonists, PSB 0739 has no risk in cervical cancer cell migration. The co-modification of acetylation and lactylation of EMT-associated proteins would be novel promising targets to develop new drug for cancer cell migration beyond contributing the potential mechanism of the use of PSB0379 in human cervical cancer cells. |
| HostingRepository | iProX |
| AnnounceDate | 2023-04-06 |
| AnnouncementXML | Submission_2023-04-05_23:33:55.347.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Miaomiao Lin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue; lactic acid |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-04-05 23:33:46 | ID requested | |
| ⏵ 1 | 2023-04-05 23:33:55 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: P2Y12, cervical cancer cells, EMT, PTM, acetylation, lactylation |
Contact List
| Yong Tang | |
|---|---|
| contact affiliation | International Collaborative Centre on Big Science Plan for Purinergic Signaling; School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine |
| contact email | tangyong@cdutcm.edu.cn |
| lab head | |
| Miaomiao Lin | |
| contact affiliation | School of Sports Medicine and Health, Chengdu Sports University |
| contact email | lin_miaomiao97@sina.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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