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PXD041365

PXD041365 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCKB catalyzes BCAR1 phosphorylation to regulate DNA damage repair
DescriptionCreatine kinase (CK) is an essential metabolic enzyme mediating creatine/phosphocreatine interconversion and shuttle to replenish ATP for energy needs. Ablation of CK causes deficiency in energy supply that eventually results in reduced muscle burst activity and neurological disorders in mice. Besides the well-established role of CK in energy-buffering, the mechanism underlying non-metabolic function of CK is poorly understood. Here we demonstrate that creatine kinase brain-type (CKB) may function as a protein kinase to regulate BCAR1 Y327 phosphorylation that enhances the association between BCAR1 and RBBP4. Then the complex of BCAR1 and RPPB4 binds to the promoter region of DNA damage repair gene RAD51 and activates its transcription by modulating histone H4K16 acetylation to ultimately promote DNA damage repair. These findings reveal the possible role of CKB independently of its metabolic function and depict the potential pathway of CKB-BCAR1-RBBP4 operating in DNA damage repair.
HostingRepositoryiProX
AnnounceDate2023-04-05
AnnouncementXMLSubmission_2023-05-22_00:47:13.264.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBo Yang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-04-05 19:55:26ID requested
12023-04-05 19:55:41announced
22023-05-22 00:47:14announced2023-05-22: Update publication information.
Publication List
Yang B, Zhang W, Sun L, Lu B, Yin C, Zhang Y, Jiang H, Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair. iScience, 26(5):106684(2023) [pubmed]
Keyword List
submitter keyword: creatine kinase brain-type (CKB), BCAR1 phosphorylation, RPPB4, DNA damage repair
Contact List
Hong Jiang
contact affiliationShanghai Institute of Organic Chemistry
contact emailhongjiang@sioc.ac.cn
lab head
Bo Yang
contact affiliationEast China Normal University
contact emailyangbo6674@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI