PXD041355

PXD041355 is an original dataset announced via ProteomeXchange.

Title	Identification of an outer membrane protease of Rickettsia rickettsii responsible for maturation of surface exposed autotransporters
Description	Strains of R. rickettsii, the agent of Rocky Mountain spotted fever, differ greatly in the severity of the disease caused. The genetic differences responsible for this disparity are only now being uncovered. An avirulent, laboratory adapted strain of R. rickettsii fails to proteolytically process several large surface protein antigens. We have identified a protease that cleaves the protein precursors to their mature form. The gene encoding this protease is mutated in the avirulent strain. Complementation of the active form of the gene identifies proteolytic processing of surface antigens as important to virulence.
HostingRepository	PRIDE
AnnounceDate	2023-07-06
AnnouncementXML	Submission_2023-07-06_13:02:30.180.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	YixiangZhang
SpeciesList	scientific name: Rickettsia rickettsii str. 'Sheila Smith'; NCBI TaxID: 392021; scientific name: Rickettsia rickettsii str. Iowa; NCBI TaxID: 452659;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-05 09:43:50	ID requested
⏵ 1	2023-07-06 13:02:30	announced

Dataset with its publication pending

submitter keyword: autotransporter,Rickettsia rickettsii

TedHackstadt
contact affiliation	Host-Parasite Interactions Section, RML/NIAID/NIH
contact email	ted.hackstadt@nih.gov
lab head
YixiangZhang
contact affiliation	Indiana University
contact email	alexzhangyx@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD041355

PRIDE project URI

• PRIDE
  1. PXD041355
     1. Label: PRIDE project
     2. Name: Identification of an outer membrane protease of Rickettsia rickettsii responsible for maturation of surface exposed autotransporters